{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:23:11Z","timestamp":1787030591419,"version":"build-2736575974"},"reference-count":46,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>Circulating endothelial cells (CEC), von Willebrand factor (vWF) antigen, P-selectin, and thrombomodulin are released from damaged endothelium, while decreases in circulating endothelial progenitor cells (CEPC) have been associated with poor vascular outcomes. We examined these markers in the peripheral blood of patients with juvenile dermatomyositis (JDM) and their correlations with disease assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Peripheral blood endothelial cells and biomarkers were assessed in 20 patients with JDM and matched healthy controls. CEC and CEPC were measured by flow cytometry, while vWF antigen and activity, factor VIII, P-selectin, and thrombomodulin were measured in plate-based assays. Disease activity and damage, nailfold capillary density, and brachial artery flow dilation were assessed. Serum cytokines\/chemokines were measured by Luminex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      CEC, vWF antigen, factor VIII, and thrombomodulin, but not vWF activity, CEPC, or P-selectin, were elevated in the peripheral blood of patients with JDM. CEC correlated with pulmonary activity (r\n                      <jats:sub>s<\/jats:sub>\n                      = 0.56). The vWF antigen correlated with Patient\u2019s\/Parent\u2019s Global, cutaneous, and extramuscular activity (r\n                      <jats:sub>s<\/jats:sub>\n                      = 0.47\u20130.54). CEPC negatively correlated with muscle activity and physical function (r\n                      <jats:sub>s<\/jats:sub>\n                      = \u22120.52 to \u22120.53). CEPC correlated inversely with endocrine damage. The vWF antigen and activity correlated with interleukin 10 and interferon-gamma inducible protein-10 (r\n                      <jats:sub>s<\/jats:sub>\n                      = 0.64\u20130.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Markers of endothelial injury are increased in patients with JDM and correlate with extramuscular activity. CEPC correlate inversely with muscle activity, suggesting a functional disturbance in repair mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.181275","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T12:15:18Z","timestamp":1564661718000},"page":"1011-1018","source":"Crossref","is-referenced-by-count":38,"title":["Endothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis"],"prefix":"10.3899","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-1562","authenticated-orcid":false,"given":"Takayuki","family":"Kishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvina","family":"Evereklian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh","family":"Nghiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryalice","family":"Stetler-Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Rick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Centola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-2458","authenticated-orcid":false,"given":"Lisa G.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"2023121610202974000_47.7.1011.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.48"},{"key":"2023121610202974000_47.7.1011.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270402"},{"key":"2023121610202974000_47.7.1011.3","doi-asserted-by":"publisher","DOI":"10.1186\/1740-2557-3-2"},{"key":"2023121610202974000_47.7.1011.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2011.11.003"},{"key":"2023121610202974000_47.7.1011.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.20116"},{"key":"2023121610202974000_47.7.1011.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken486"},{"key":"2023121610202974000_47.7.1011.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.27418"},{"key":"2023121610202974000_47.7.1011.8","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200105)44:5<1203::AID-ANR204>3.0.CO;2-C"},{"key":"2023121610202974000_47.7.1011.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes152"},{"key":"2023121610202974000_47.7.1011.10","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000041"},{"key":"2023121610202974000_47.7.1011.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.81"},{"key":"2023121610202974000_47.7.1011.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew288"},{"key":"2023121610202974000_47.7.1011.13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12969-017-0171-3","article-title":"Endothelial progenitor cell number is not decreased in 34 children with juvenile dermatomyositis: a pilot study","volume":"15","author":"Xu","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"2023121610202974000_47.7.1011.14","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"2023121610202974000_47.7.1011.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.22164"},{"key":"2023121610202974000_47.7.1011.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390910"},{"key":"2023121610202974000_47.7.1011.17","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20532"},{"key":"2023121610202974000_47.7.1011.18","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev344"},{"key":"2023121610202974000_47.7.1011.19","first-page":"1644","article-title":"Skin involvement in juvenile dermatomyositis is associated with loss of end row nailfold capillary loops","volume":"31","author":"Smith","year":"2004","journal-title":"J Rheumatol"},{"key":"2023121610202974000_47.7.1011.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.10.008"},{"key":"2023121610202974000_47.7.1011.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.12.007"},{"key":"2023121610202974000_47.7.1011.22","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000151690.43777.e4"},{"key":"2023121610202974000_47.7.1011.23","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1172\/JCI108160","article-title":"Studies of the human factor VIII\/von Willebrand factor protein. 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