{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:25:11Z","timestamp":1793125511409,"version":"4.5.0"},"reference-count":21,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To determine whether positive anticentromere antibody (ACA) serology affects the severity of sicca symptoms in patients with primary Sj\u00f6gren syndrome (pSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Evaluation to detect subjective and objective sicca symptoms included questionnaires, physical examination, and pathology. Cases of pSS were classified according to the 2002 American-European Consensus Group (AECG) criteria. All patients were evaluated for presence of anti-Ro, anti-La, and ACA serology. Patients with pSS were categorized into ACA+ SS and ACA\u2013SS. The groups were compared for measures of severity of oral and ocular sicca.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The pSS group had 446 patients, of whom 26 were ACA+ SS. Subjective ocular sicca measured 7.0 \u00b1 2.4 (out of 10) in ACA+ SS and 6.4 \u00b1 2.6 in ACA\u2013SS (p = 0.197). Objective ocular sicca measured 3.2 mm \u00b1 1.8 mm\/5 min in ACA+ SS and 4.2 mm \u00b1 4.4 mm\/5 min in ACA\u2013SS (p = 0.038). Subjective oral sicca measured 8.5 \u00b1 1.4 in ACA+ SS and 6.7 \u00b1 2.4 in ACA\u2013SS (p &lt; 0.001). Objective oral sicca measured 0.1 ml \u00b1 0.2 ml\/15 min in ACA+ SS and 0.4 ml \u00b1 1.0 ml\/15 min in ACA\u2013SS (p &lt; 0.001). Only 35% of ACA+ patients with SS were anti-Ro\u2013positive or anti-La\u2013positive compared with 77% of the ACA\u2013patients with SS (p &lt; 0.001). There was no significant difference in minor salivary gland fibrosis or focus scores between ACA+ SS and ACA\u2013patients with SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>ACA+ SS is associated with more severe objective ocular sicca and more severe subjective and objective oral sicca compared to ACA\u2013SS. The majority of ACA+ patients with SS meet AECG criteria for pSS despite negative serology for anti-Ro\/La antibodies.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.190462","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T20:10:50Z","timestamp":1571170250000},"page":"876-880","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Effect on Sicca Symptoms of Anticentromere Antibody\u2013positive Sj\u00f6gren Syndrome and Primary Sj\u00f6gren Syndrome Alone"],"prefix":"10.3899","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-2129","authenticated-orcid":false,"given":"Yifan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.M.","family":"Bookman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"2020060113043406000_47.6.876.1","unstructured":"Hollander JL . 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