{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:05:55Z","timestamp":1784559955573,"version":"3.55.0"},"reference-count":33,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess the effect of clinical enthesitis by body site in patients with psoriatic arthritis (PsA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Adults with PsA enrolled in the Corrona Psoriatic Arthritis\/Spondyloarthritis Registry (March 2013\u2013March 2018) were included. Enthesitis at enrollment was assessed by the Spondyloarthritis Research Consortium of Canada Enthesitis Index and classified by affected sites (upper, lower, or both). Disease activity (e.g., Clinical Disease Activity Index, Clinical Disease Activity Index for PsA), patient-reported outcomes (PRO; e.g., patient-reported pain and fatigue), and work productivity were compared between those with and without enthesitis using<jats:italic>t<\/jats:italic>- or Wilcoxon rank-sum tests for continuous variables and chi-square or Fisher exact tests for categorical variables. The association of enthesitis with disease activity and PRO measures versus no enthesitis was modeled using multivariable-adjusted linear or logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of 2003 patients with PsA, 391 (19.5%) had enthesitis: 80 (20.5%) in upper sites only; 137 (35.0%) in lower sites only; and 174 (44.5%) in both. Regardless of location, disease activity and PRO were worse in patients with versus without enthesitis. In adjusted models, the presence of enthesitis at any site was significantly associated with worse disease activity versus no enthesitis. Enthesitis in lower or both upper and lower sites was associated with higher pain and fatigue scores and greater work impairment versus no enthesitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with clinical enthesitis had worse disease activity regardless of enthesitis location versus those without enthesitis, and patients with enthesitis in lower or both upper and lower sites had worse pain, fatigue, and work impairment.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.191117","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T19:45:18Z","timestamp":1591040718000},"page":"367-375","source":"Crossref","is-referenced-by-count":19,"title":["Disease Characteristics, Quality of Life, and Work Productivity by Enthesitis Site: Real-world Data From the US Corrona Psoriatic Arthritis\/Spondyloarthritis Registry"],"prefix":"10.3899","volume":"48","author":[{"given":"Philip J.","family":"Mease","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Rebello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-0775","authenticated-orcid":false,"given":"Alexis","family":"Ogdie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"2022070101451361000_48.3.367.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.003"},{"key":"2022070101451361000_48.3.367.2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/art.39573","article-title":"Group for research and assessment of psoriasis and psoriatic arthritis 2015 treatment recommendations for psoriatic arthritis","volume":"68","author":"Coates","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2022070101451361000_48.3.367.3","first-page":"1435","article-title":"Therapies for psoriatic enthesopathy. A systematic review","volume":"33","author":"Ritchlin","year":"2006","journal-title":"J Rheumatol"},{"key":"2022070101451361000_48.3.367.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"2022070101451361000_48.3.367.5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semarthrit.2017.12.008","article-title":"Enthesitis: a hallmark of psoriatic arthritis","volume":"48","author":"Kaeley","year":"2018","journal-title":"Semin Arthritis Rheum"},{"key":"2022070101451361000_48.3.367.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.22758"},{"key":"2022070101451361000_48.3.367.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.09.011"},{"key":"2022070101451361000_48.3.367.8","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s10067-016-3319-5","article-title":"Psoriatic nail involvement and its relationship with distal interphalangeal joint disease","volume":"35","author":"Lai","year":"2016","journal-title":"Clin Rheumatol"},{"key":"2022070101451361000_48.3.367.9","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ad.2015.02.005","article-title":"Nail psoriasis as a predictor of the development of psoriatic arthritis","volume":"106","author":"Raposo","year":"2015","journal-title":"Actas Dermosifiliogr"},{"key":"2022070101451361000_48.3.367.10","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/acr.23174","article-title":"Clinical enthesitis in a prospective longitudinal psoriatic arthritis cohort: incidence, prevalence, characteristics, and outcome","volume":"69","author":"Polachek","year":"2017","journal-title":"Arthritis Care Res"},{"key":"2022070101451361000_48.3.367.11","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/acr.23249","article-title":"Clinical characteristics, disease activity, and patient-reported outcomes in psoriatic arthritis patients with dactylitis or enthesitis: results from the Corrona Psoriatic Arthritis\/Spondyloarthritis Registry","volume":"69","author":"Mease","year":"2017","journal-title":"Arthritis Care Res"},{"key":"2022070101451361000_48.3.367.12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13075-017-1399-5","article-title":"The association between sonographic enthesitis and radiographic damage in psoriatic arthritis","volume":"19","author":"Polachek","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"2022070101451361000_48.3.367.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.03.007"},{"key":"2022070101451361000_48.3.367.14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/art.39458","article-title":"Review: enthesitis: new insights into pathogenesis, diagnostic modalities, and treatment","volume":"68","author":"Kehl","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2022070101451361000_48.3.367.15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.berh.2018.07.011","article-title":"Born to run: the paradox of biomechanical force in spondyloarthritis from an evolutionary perspective","volume":"31","author":"Debusschere","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2022070101451361000_48.3.367.16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.berh.2018.12.001","article-title":"Advances in understanding the pathophysiology of spondyloarthritis","volume":"32","author":"Lories","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2022070101451361000_48.3.367.17","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102053"},{"key":"2022070101451361000_48.3.367.18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084244"},{"key":"2022070101451361000_48.3.367.19","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203643"},{"key":"2022070101451361000_48.3.367.20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.013599"},{"key":"2022070101451361000_48.3.367.21","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121145"},{"key":"2022070101451361000_48.3.367.22","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/1756-185X.12505","article-title":"Sleep quality in patients with psoriatic arthritis","volume":"20","author":"Gezer","year":"2017","journal-title":"Int J Rheum Dis"},{"key":"2022070101451361000_48.3.367.23","doi-asserted-by":"publisher","DOI":"10.1002\/art.23568"},{"key":"2022070101451361000_48.3.367.24","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1007\/s00296-011-2190-6","article-title":"Which clinical variables have the most significant correlation with quality of life evaluated by SF-36 survey in a Croatian cohort of patients with ankylosing spondylitis and psoriatic arthritis?","volume":"32","author":"Jaji\u0107","year":"2012","journal-title":"Rheumatol Int"},{"key":"2022070101451361000_48.3.367.25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/1756-185X.12283","article-title":"Is the health-related quality of life and functional status of patients with psoriatic arthritis worse than that of patients with psoriasis alone?","volume":"18","author":"Tezel","year":"2015","journal-title":"Int J Rheum Dis"},{"key":"2022070101451361000_48.3.367.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.03.005"},{"key":"2022070101451361000_48.3.367.27","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20577"},{"key":"2022070101451361000_48.3.367.28","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.semarthrit.2017.10.021","article-title":"Considerations for the definition of remission criteria in psoriatic arthritis","volume":"47","author":"Mease","year":"2018","journal-title":"Semin Arthritis Rheum"},{"key":"2022070101451361000_48.3.367.29","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151491"},{"key":"2022070101451361000_48.3.367.30","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110893"},{"key":"2022070101451361000_48.3.367.31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/rheumatology\/kex079","article-title":"The problem in differentiation between psoriatic-related polyenthesitis and fibromyalgia","volume":"57","author":"Marchesoni","year":"2018","journal-title":"Rheumatology"},{"key":"2022070101451361000_48.3.367.32","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204239"},{"key":"2022070101451361000_48.3.367.33","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12442112"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.191117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:11:42Z","timestamp":1696191102000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.191117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,1]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.3899\/jrheum.191117"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.191117","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}