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Metaanalysis was performed to identify overall prevalence rate and OR of HL, as well as to compare mean differences in frequency-specific hearing thresholds between patients with and without AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Our metaanalysis included 14 studies and 1083 patients (598 with AS vs 485 without AS). The pooled prevalence of HL in patients with AS was 42.4% (95% CI 29.2\u201356.2). Patients with AS had a significantly higher OR of HL than patients without AS (OR 4.65, 95% CI 2.73\u20137.91). Mean differences in pure-tone hearing thresholds ranged from 0\u20135 decibels (dB) for frequencies of 0.25\u20134 kHz, and from 5\u201315 dB for frequencies of 6\u201316 kHz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with AS have higher odds of having HL than patients without AS. The AS population also presents with significantly impaired hearing thresholds across all conventional and extended pure-tone frequencies. This may manifest as slight to moderate HL. Results of this systematic review might justify increased attention to audiologic manifestations of patients with AS.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.200276","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:22:03Z","timestamp":1589559723000},"page":"40-47","source":"Crossref","is-referenced-by-count":12,"title":["Hearing Loss in Patients With Ankylosing Spondylitis: A Systematic Review and Metaanalysis"],"prefix":"10.3899","volume":"48","author":[{"given":"Flora","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka D.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted A.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"2022062114101678000_48.1.40.1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10067-017-3651-4","article-title":"Prevalence of hearing impairment in patients with rheumatoid arthritis, granulomatosis with polyangiitis (GPA, Wegener\u2019s granulomatosis), or systemic lupus erythematosus","volume":"36","author":"Rahne","year":"2017","journal-title":"Clin Rheumatol"},{"key":"2022062114101678000_48.1.40.2","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1177\/0300060516688600","article-title":"Systemic lupus erythematosus and hearing disorders: literature review and meta-analysis of clinical and temporal bone findings","volume":"45","author":"Di Stadio","year":"2017","journal-title":"J Int Med Res"},{"key":"2022062114101678000_48.1.40.3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10067-017-3959-0","article-title":"Early hearing loss detection in rheumatoid arthritis and primary Sj\u00f6gren syndrome using extended high frequency audiometry","volume":"37","author":"Galarza-Delgado","year":"2018","journal-title":"Clin Rheumatol"},{"key":"2022062114101678000_48.1.40.4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140559"},{"key":"2022062114101678000_48.1.40.5","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318173aa56"},{"key":"2022062114101678000_48.1.40.6","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200001000-00006"},{"key":"2022062114101678000_48.1.40.7","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.autrev.2018.01.014","article-title":"Hearing loss in autoimmune disorders: Prevalence and therapeutic options","volume":"17","author":"Mancini","year":"2018","journal-title":"Autoimmun Rev"},{"key":"2022062114101678000_48.1.40.8","first-page":"589","article-title":"Sudden sensorineural hearing loss in patients with systemic lupus erythematosus or lupus-like syndromes and antiphospholipid antibodies","volume":"25","author":"Naarendorp","year":"1998","journal-title":"J Rheumatol"},{"key":"2022062114101678000_48.1.40.9","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600606723"},{"key":"2022062114101678000_48.1.40.10","doi-asserted-by":"crossref","unstructured":"Kessel A , Vadasz Z , Toubi E. 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