{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:53:15Z","timestamp":1785268395343,"version":"3.55.0"},"reference-count":31,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>The risk of clinically manifested major cardiovascular (CV) events in primary Sj\u00f6gren syndrome (pSS) remains unclear. This study aimed to assess myocardial fibrosis in pSS and investigate the associated disease characteristics by cardiac magnetic resonance imaging (cMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We performed a cross-sectional study of patients with pSS without cardiac symptoms. Labial gland biopsy was documented in 44 patients (85%). Patients without CV risk factors underwent contrast-enhanced cMRI. Late gadolinium enhancement (LGE) was used to assess myocardial fibrosis. Myocardial edema was assessed using T2-weighted imaging (T2WI). We compared the left ventricular (LV) geometry and function between the groups with and without LGE. Further, we explored the associations of cMRI abnormalities with pSS characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Fifty-two women with pSS (median age 55, IQR 47.0\u201365.7 yrs) were enrolled in the study. LGE was observed in 10 patients (19%), two of whom showed high intensity on T2WI. High intensity on T2WI was observed in 3 patients (5.8%). LV mass index and LV mass\/end-diastolic volume tended to be higher in the LGE-positive group than in the LGE-negative group (<jats:italic>P<\/jats:italic> = 0.078 and 0.093, respectively). Salivary gland focus score (FS) \u2265 3 was independently associated with LGE-positive in the multivariable analysis (OR 11.21, 95% CI 1.18\u2013106.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Subclinical myocardial fibrosis, as detected by cMRI, was frequent in patients with pSS without cardiac symptoms. Abnormal cMRI findings were associated with salivary gland FS \u2265 3.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.200352","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T16:22:16Z","timestamp":1600186936000},"page":"859-866","source":"Crossref","is-referenced-by-count":12,"title":["Salivary Gland Focus Score Is Associated With Myocardial Fibrosis in Primary Sj\u00f6gren Syndrome Assessed by a Cardiac Magnetic Resonance 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