{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:44:51Z","timestamp":1790747091410,"version":"4.1.0"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Colchicine has been considered a lifelong therapy for familial Mediterranean fever (FMF). Recent studies describe patients who discontinued colchicine, but there is a lack of data pertaining to predictors of success. The aims of our study were to describe a cohort of pediatric patients with FMF who discontinued colchicine therapy, and to identify factors predicting successful termination of colchicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study describes a cohort of pediatric patients with FMF who discontinued colchicine therapy following a relatively prolonged attack-free period (&gt; 6 months), and identifies factors predicting successful termination. Data collected included demographic, clinical, and laboratory characteristics of children diagnosed with FMF aged &lt; 16 years who underwent a trial of colchicine discontinuation. Data from patients who successfully ceased colchicine therapy were compared to those of patients who relapsed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 571 patients with FMF, 59 (10.3%) discontinued colchicine therapy. The average attack-free period before enrollment was 0.97 \u00b1 1.4 years. Follow-up after ceasing colchicine was 5.0 \u00b1 3.05 years, during which time 11 (20%) patients had an attack. The most common symptoms were fever (100%) and abdominal pain (80%). For those failing discontinuation, colchicine was restarted within 1.3 years (range 0.3\u20135.0, median 0.7 yrs). A longer attack-free period prior to colchicine discontinuation predicted success. Myalgia and arthritis prior to colchicine cessation were more common among children who required renewal of colchicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cessation of colchicine therapy should be considered following prolonged remission in a select group of patients. Patients with arthritis or myalgia are more likely to have an attack after ceasing colchicine therapy.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.201158","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T12:20:21Z","timestamp":1621081221000},"page":"1732-1735","source":"Crossref","is-referenced-by-count":9,"title":["Discontinuation of Colchicine Therapy in Children With Familial Mediterranean Fever"],"prefix":"10.3899","volume":"48","author":[{"given":"Yonatan Butbul","family":"Aviel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silman","family":"Rawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafe","family":"Fahoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9823-4750","authenticated-orcid":false,"given":"Yackov","family":"Berkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"2022062114101785000_48.11.1732.1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/JIR.S91352","article-title":"Familial Mediterranean fever: current perspectives","volume":"9","author":"Ozen","year":"2016","journal-title":"J Inflamm Res"},{"key":"2022062114101785000_48.11.1732.2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/BOR.0000000000000315","article-title":"Familial Mediterranean fever","volume":"28","author":"Padeh","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"2022062114101785000_48.11.1732.3","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4860"},{"key":"2022062114101785000_48.11.1732.4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.autrev.2014.01.045","article-title":"Diagnostic criteria of familial Mediterranean fever","volume":"13","author":"Berkun","year":"2014","journal-title":"Autoimmunity Review"},{"key":"2022062114101785000_48.11.1732.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604173141601"},{"key":"2022062114101785000_48.11.1732.6","first-page":"261","article-title":"[Familial Mediterranean Fever (FMF): from diagnosis to treatment]","volume":"14","author":"Medlej-Hashim","year":"2004","journal-title":"[Article in French] Sante"},{"key":"2022062114101785000_48.11.1732.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.047"},{"key":"2022062114101785000_48.11.1732.8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10067-016-3421-8","article-title":"Discontinuing colchicine in symptomatic carriers for MEFV (Mediterranean FeVer) variants","volume":"36","author":"S\u00f6nmez","year":"2017","journal-title":"Clin Rheumatol"},{"key":"2022062114101785000_48.11.1732.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401023"},{"key":"2022062114101785000_48.11.1732.10","unstructured":"Gattorno M , Hofer M , Federici S , Vanoni F , Bovis F , Aksentijevich I , ; Eurofever Registry and the Paediatric Rheumatology International Trials Organisation (PRINTO) . 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Ann Rheum Dis 2019 1025-32."},{"key":"2022062114101785000_48.11.1732.11","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-3"},{"key":"2022062114101785000_48.11.1732.12","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/1756-185X.12929","article-title":"Familial Mediterranean fever patients homozygous for E148Q variant may have milder disease","volume":"21","author":"Topaloglu","year":"2018","journal-title":"Int J Rheum Dis"},{"key":"2022062114101785000_48.11.1732.13","doi-asserted-by":"crossref","first-page":"e22852","DOI":"10.1002\/jcla.22852","article-title":"Clinical features and disease severity of Turkish FMF children carrying E148Q mutation","volume":"33","author":"Ayd\u0131n","year":"2019","journal-title":"J Clin Lab Anal"},{"key":"2022062114101785000_48.11.1732.14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00296-017-3796-0","article-title":"Familial Mediterranean fever in childhood: a single-center experience","volume":"38","author":"Barut","year":"2018","journal-title":"Rheumatol Int"},{"key":"2022062114101785000_48.11.1732.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.37935"},{"key":"2022062114101785000_48.11.1732.16","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/rheumatology\/kez156","article-title":"Short-term follow-up results of children with familial Mediterranean fever after cessation of colchicine: is it possible to quit?","volume":"58","author":"Tanatar","year":"2019","journal-title":"Rheumatology"},{"key":"2022062114101785000_48.11.1732.17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208690"},{"key":"2022062114101785000_48.11.1732.18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jpeds.2018.08.080","article-title":"Familial Mediterranean fever is commonly diagnosed in children in Israel with periodic fever aphthous stomatitis, pharyngitis, and adenitis syndrome","volume":"204","author":"Butbul Aviel","year":"2019","journal-title":"J Pediatr"},{"key":"2022062114101785000_48.11.1732.19","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090687"},{"key":"2022062114101785000_48.11.1732.20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.semarthrit.2019.08.004","article-title":"Performance of the new \u2018Eurofever\/PRINTO classification criteria\u2019 in FMF patients","volume":"50","author":"Sag","year":"2020","journal-title":"Semin Arthritis Rheum"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.201158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T21:10:55Z","timestamp":1655845855000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.201158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,1]]},"published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.3899\/jrheum.201158"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.201158","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]}}}