{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:51:00Z","timestamp":1740153060569,"version":"3.37.3"},"reference-count":12,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"accepted":{"date-parts":[[2023,9,8]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study changes in retention of first biologic disease-modifying antirheumatic drug (DMARD) therapy over a period of 15 years in an inception cohort of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed patient and disease characteristics and drug survival of patients starting a biologic (tumor necrosis factor inhibitor [TNFi]) therapy between 2004 and 2019 in routine care at the Amsterdam Rheumatology and Immunology Center, Reade, the Netherlands. Starts were classified as early (2004-2008), intermediate (2009-2013), and recent (2014-2018). Kaplan-Meier plots and log-rank tests assessed the overall difference in drug survival between the 3 observation groups and between diagnoses, followed by Cox regression to estimate hazard ratios (HRs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1938 consecutive patients starting TNFi therapy, 63% with RA, 19% with PsA, and 19% with AS; 65% were female. Drug survival decreased significantly over time (overall<jats:italic>P<\/jats:italic>&lt; 0.001), mostly caused by decreases in the most recent 4-year period. The HR for drug continuation was 2.04 (95% CI 1.71-2.43,<jats:italic>P<\/jats:italic>&lt; 0.001) for the early vs the recent group and 1.92 (95% CI 1.58-2.35,<jats:italic>P<\/jats:italic>&lt; 0.001) for the intermediate vs the recent group. Drug survival time was significantly different between diseases (overall<jats:italic>P<\/jats:italic>&lt; 0.001), mostly caused by shorter survival in RA. The HR for drug continuation was 0.58 (95% CI 0.47-0.73,<jats:italic>P<\/jats:italic>&lt; 0.001) for RA vs PsA and 0.63 (95% CI 0.51-0.78,<jats:italic>P<\/jats:italic>&lt; 0.001) for RA vs AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with RA, PsA, and AS currently initiating biologic (TNFi) therapy discontinue the drug much sooner than those starting shortly after the drugs were introduced. This is most likely because of the availability of alternative novel biologic and targeted synthetic DMARD treatments and treat-to-target protocols enabling and necessitating earlier switching.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.2023-0149","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:20:28Z","timestamp":1694780428000},"page":"84-87","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Tumor Necrosis Factor Inhibitor Drug Survival in Patients With Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis Over 15 Years"],"prefix":"10.3899","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3456-9786","authenticated-orcid":false,"given":"Ingrid M.","family":"Visman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaf","family":"Atiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-283X","authenticated-orcid":false,"given":"Maarten","family":"Boers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W.R.","family":"Twisk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-1934","authenticated-orcid":false,"given":"Michael T.","family":"Nurmohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"2024030708001982000_51.1.84.1","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1002\/ddr.21192","article-title":"Ten-year drug survival of anti-TNF agents in the treatment of inflammatory arthritides","volume":"75","author":"Biggioggero","year":"2014","journal-title":"Drug Dev Res"},{"key":"2024030708001982000_51.1.84.2","doi-asserted-by":"crossref","first-page":"151979","DOI":"10.1016\/j.semarthrit.2022.151979","article-title":"Drug survival of biologics and novel immunomodulators for rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, and psoriasis \u2013 a nationwide cohort study from the DANBIO and DERMBIO registries","volume":"53","author":"Egeberg","year":"2022","journal-title":"Semin Arthritis Rheum"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.3","DOI":"10.1001\/jama.2018.13103"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.4","DOI":"10.1136\/annrheumdis-2019-216655"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.5","DOI":"10.1136\/annrheumdis-2020-217159"},{"unstructured":"World Health Organization . Biologicals and tsDMARDs in inflammatory rheumatic diseases: The Reade Rheumatology Registry. [Internet. Accessed September 21, 2023.] Available from: https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=NTR6868","key":"2024030708001982000_51.1.84.6"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.7","DOI":"10.1136\/annrheumdis-2015-207524"},{"key":"2024030708001982000_51.1.84.8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.rdc.2019.07.002","article-title":"Treat to target in psoriatic arthritis","volume":"45","author":"Zhang","year":"2019","journal-title":"Rheum Dis Clin North Am"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.9","DOI":"10.1016\/j.jaut.2019.102398"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.10","DOI":"10.1136\/annrheumdis-2013-204128"},{"doi-asserted-by":"publisher","key":"2024030708001982000_51.1.84.11","DOI":"10.1136\/annrheumdis-2021-eular.1895"},{"key":"2024030708001982000_51.1.84.12","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1093\/rheumatology\/keab945","article-title":"European bio-na\u00efve spondyloarthritis patients initiating TNF inhibitor: time trends in baseline characteristics, treatment retention and response","volume":"61","author":"Christiansen","year":"2022","journal-title":"Rheumatology"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.2023-0149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T16:02:08Z","timestamp":1709827328000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.2023-0149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.3899\/jrheum.2023-0149"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.2023-0149","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"type":"print","value":"0315-162X"},{"type":"electronic","value":"1499-2752"}],"subject":[],"published":{"date-parts":[[2023,9,15]]}}}