{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:23:13Z","timestamp":1787030593690,"version":"build-2736575974"},"reference-count":44,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"accepted":{"date-parts":[[2023,11,23]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Takayasu arteritis (TA) leads to stenotic disease. Aneurysmal lesions are rarer. This study assessed the main characteristics of aneurysmal disease in a Canadian cohort of patients with TA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This monocentric retrospective study included patients with TA followed at the Mount Sinai Hospital Vasculitis Clinic in Toronto. Diagnosis of TA was based on clinical findings and\/or satisfied the 1990 American College of Rheumatology classification criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-four patients were included. At any time, aneurysmal disease was found in 23 (31%) patients. Median disease duration was 9.0 (IQR 7.0-19.0) years. Prior hypertension (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02), fever (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04), and seizure disorders (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03) were more common. Limb claudication was less frequent (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01). Persistent and\/or new aneurysms were demonstrated in 22\/23 patients at follow-up. Thoracic aorta aneurysm (13\/22) was most common, followed by abdominal aorta (8\/22), subclavian (7\/22), and carotid (6\/22) artery disease. Aortic valve regurgitation was more frequent (9\/23 vs 3\/48;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). Twenty-one patients had been treated with glucocorticoids (median 6.1 years [IQR 3.7-8.1]). Methotrexate, azathioprine, and leflunomide were repeatedly used. Infliximab (7\/23) was used more often (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04), whereas tocilizumab was received by only 4 patients with aneurysmal disease (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01). Patients with aneurysms suffered more frequent relapses (2.0 [IQR 0.0-4.0] vs 1.0 [IQR 0.0-2.0],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aneurysmal disease was found in a significant proportion of patients with TA. Given that aneurysms may carry a risk of rupture, and are associated with a higher rate of relapse, this finding should be reported systematically in TA studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.2023-0629","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T08:25:16Z","timestamp":1702628716000},"page":"277-284","source":"Crossref","is-referenced-by-count":4,"title":["Aneurysmal Disease in Patients With Takayasu 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