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Under inflammatory conditions, chondrocytes increase production levels of inflammatory cytokines and cartilage-degrading enzymes, which further drive cartilage destruction. Chondrocytes also have an innate immune function and respond to damage-associated molecular patterns (DAMPs) and cartilage fragments by innate immune receptors. In addition, chondrocytes play a role in adaptive immune responses by acting as antigen-presenting cells and presenting cartilaginous antigens to T cells. Indirectly, chondrocytes are stimulated by pathogen-associated molecular patterns (PAMPs) present in the joints, a result of the microbiota of the host. Chondrocytes have both direct and indirect relationships with immune cells and the immune compartment of patients with OA. Therefore, chondrocytes serve as a target for immunotherapeutic approaches in OA. In this narrative review, we cover the aforementioned immune-related aspects of chondrocytes in OA.<\/jats:p>","DOI":"10.3899\/jrheum.2023-0816","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:27:40Z","timestamp":1698827260000},"page":"13-24","source":"Crossref","is-referenced-by-count":58,"title":["The Immunological Facets of Chondrocytes in Osteoarthritis: A Narrative 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