{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:31:38Z","timestamp":1714609898588},"reference-count":35,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"accepted":{"date-parts":[[2024,1,22]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Infectious conditions are a significant cause of mortality in autoimmune rheumatic diseases (ARD). Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective analysis included members of the largest health maintenance organization in Israel, aged &gt; 18 years at the first episode of infection, who required hospitalization during 2003-2019. We compared in-hospital mortality and the results of a 3-year landmark analysis of those who survived the index hospitalization between patients with ARD, according to disease subgroups, and patients without ARD. Additionally, we compared mortality outcomes among patients with ARD, according to subgroup diagnosis, matched in a 1:3 ratio by age, sex, and ethnicity to patients without ARD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Included were 365,247 patients who were admitted for the first time with the diagnosis of a serious infection. Of these, we identified 9755 with rheumatoid arthritis (RA), 1351 with systemic lupus erythematosus, 2120 with spondyloarthritis (SpA), 584 with systemic sclerosis, and 3214 with vasculitis. In a matched multivariate analysis, the risk for in-hospital mortality was lower among patients with RA (odds ratio [OR] 0.89, 95% CI 0.81-0.97) and SpA (OR 0.77, 95% CI 0.63-0.94). In a similar analysis, the risk of 3-year mortality was lower among patients with RA (hazard ratio [HR] 0.82, 95% CI 0.78-0.86) and vasculitis (HR 0.86, 95% CI 0.80-0.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients hospitalized for an infection, the risk of in-hospital and 3-year mortality was not increased among those with ARD compared to those without ARD.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.2023-1063","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T13:25:35Z","timestamp":1706793935000},"page":"517-522","source":"Crossref","is-referenced-by-count":0,"title":["Short- and Long-Term Mortality of Hospitalized Patients With Autoimmune Rheumatic Diseases and Serious Infections: A National Cohort Study"],"prefix":"10.3899","volume":"51","author":[{"given":"Iftach","family":"Sagy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Schwarzfuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit Shira","family":"Babiev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Abu-Shakra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"2024050105200868000_51.5.517.1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21812"},{"key":"2024050105200868000_51.5.517.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes305"},{"key":"2024050105200868000_51.5.517.3","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000011"},{"key":"2024050105200868000_51.5.517.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"2024050105200868000_51.5.517.5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/BOR.0000000000000870","article-title":"The safety of glucocorticoids in the treatment of inflammatory rheumatic disease: new evidence","volume":"34","author":"Lu\u00eds","year":"2022","journal-title":"Curr Opin Rheumatol"},{"key":"2024050105200868000_51.5.517.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem076"},{"key":"2024050105200868000_51.5.517.7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2022-eular.4585"},{"key":"2024050105200868000_51.5.517.8","doi-asserted-by":"crossref","first-page":"1759720X20962618","DOI":"10.1177\/1759720X20962618","article-title":"Risk of community-acquired pneumonia requiring hospitalization in patients with spondyloarthritis","volume":"12","author":"Chung","year":"2020","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2024050105200868000_51.5.517.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.098822"},{"key":"2024050105200868000_51.5.517.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2411-7"},{"key":"2024050105200868000_51.5.517.11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/acr2.11195","article-title":"Reasons for hospitalization and in-hospital mortality in adult systemic lupus erythematosus","volume":"2","author":"Manadan","year":"2020","journal-title":"ACR Open Rheumatol"},{"key":"2024050105200868000_51.5.517.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key150"},{"key":"2024050105200868000_51.5.517.13","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101924"},{"key":"2024050105200868000_51.5.517.14","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111516"},{"key":"2024050105200868000_51.5.517.15","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221824"},{"key":"2024050105200868000_51.5.517.16","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"2024050105200868000_51.5.517.17","doi-asserted-by":"publisher","DOI":"10.1002\/art.30277"},{"key":"2024050105200868000_51.5.517.18","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa188"},{"key":"2024050105200868000_51.5.517.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2010.11.032"},{"key":"2024050105200868000_51.5.517.20","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160942"},{"key":"2024050105200868000_51.5.517.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.04.001"},{"key":"2024050105200868000_51.5.517.22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/art.41577","article-title":"Hospitalized infections in lupus: a nationwide study of types of infections, time trends, health care utilization, and in-hospital mortality","volume":"73","author":"Singh","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"2024050105200868000_51.5.517.23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00296-019-04484-5","article-title":"All-cause hospitalizations and mortality in systemic lupus erythematosus in the US: results from a national inpatient database","volume":"40","author":"Dhital","year":"2020","journal-title":"Rheumatol Int"},{"key":"2024050105200868000_51.5.517.24","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210909"},{"key":"2024050105200868000_51.5.517.25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10067-012-2131-0","article-title":"Indications for hospitalization and in-hospital mortality in Thai systemic sclerosis","volume":"32","author":"Netwijitpan","year":"2013","journal-title":"Clin Rheumatol"},{"key":"2024050105200868000_51.5.517.26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/0310057X1704500110","article-title":"Prognosis of patients with rheumatic diseases admitted to intensive care","volume":"45","author":"Beil","year":"2017","journal-title":"Anaesth Intensive Care"},{"key":"2024050105200868000_51.5.517.27","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1007\/s10067-022-06197-w","article-title":"In-ICU-acquired infections in flare-up systemic rheumatic disease patients receiving immunosuppressant","volume":"41","author":"Assan","year":"2022","journal-title":"Clin Rheumatol"},{"key":"2024050105200868000_51.5.517.28","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/rheumatology\/kew502","article-title":"Cause-specific mortality in patients with psoriatic arthritis and rheumatoid arthritis","volume":"56","author":"Ogdie","year":"2017","journal-title":"Rheumatology"},{"key":"2024050105200868000_51.5.517.29","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2019-001140"},{"key":"2024050105200868000_51.5.517.30","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq242"},{"key":"2024050105200868000_51.5.517.31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11926-019-0832-y","article-title":"In the real world: infections associated with biologic and small molecule therapies in psoriatic arthritis and psoriasis","volume":"21","author":"Siegel","year":"2019","journal-title":"Curr Rheumatol Rep"},{"key":"2024050105200868000_51.5.517.32","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/rheumatology\/key198","article-title":"Biologic prescribing decisions following serious infection: results from the British Society for Rheumatology Biologics Register-Rheumatoid Arthritis","volume":"57","author":"Subesinghe","year":"2018","journal-title":"Rheumatology"},{"key":"2024050105200868000_51.5.517.33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1692"},{"key":"2024050105200868000_51.5.517.34","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/MLR.0000000000001135","article-title":"Prediction accuracy with electronic medical records versus administrative claims","volume":"57","author":"Zeltzer","year":"2019","journal-title":"Med Care"},{"key":"2024050105200868000_51.5.517.35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.chest.2020.03.050","article-title":"One-year outcome of critically ill patients with systemic rheumatic disease: a multicenter cohort study","volume":"158","author":"Larcher","year":"2020","journal-title":"Chest"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.2023-1063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T15:03:00Z","timestamp":1714575780000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.2023-1063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,1]]},"published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.3899\/jrheum.2023-1063"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.2023-1063","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]}}}