{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T14:27:32Z","timestamp":1793543252702,"version":"4.5.0"},"reference-count":53,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"accepted":{"date-parts":[[2026,7,3]]},"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to examine the associations between physical activity (PA) levels and depressive symptoms in patients with radiographic axial spondyloarthritis (r-axSpA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional analysis of patients with r-axSpA identified from the UK Biobank. Total PA (TPA) was assessed using a modified version of the International Physical Activity Questionnaire Short Form (IPAQ-SF), and leisure-time PA (LTPA) was derived from self-reported frequency and duration of 5 leisure activities during the preceding 4 weeks. Depressive symptoms were assessed using the 2-item Patient Health Questionnaire (PHQ-2). Multivariable logistic regression models were used to examine the associations between PA levels and depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1542 patients with r-axSpA, those engaging in moderate-level PA had the lowest prevalence of depressive symptoms. After full adjustment, moderate-level TPA was associated with lower odds of depressive symptoms compared with low-level TPA (odds ratio [OR] 0.55, 95% CI 0.36-0.82), whereas the association with high-level TPA was not statistically significant (OR 0.63, 95% CI 0.39-1.01). Moderate-level LTPA was also associated with lower odds of depressive symptoms (OR 0.58, 95% CI 0.34-0.996), whereas low- and high-level LTPA showed no significant associations after full adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate-level PA was associated with a lower prevalence of depressive symptoms in patients with r-axSpA, whereas associations for high-level PA were less consistent. Our findings suggest that PA levels may be an important correlate of depressive symptoms in patients with r-axSpA, warranting confirmation in longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.2026-0065","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:20:25Z","timestamp":1784118025000},"page":"1221-1228","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Physical Activity Levels With Depressive Symptoms Among Patients With Radiographic Axial Spondyloarthritis: A Cross-Sectional 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