{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:51:48Z","timestamp":1792068708919,"version":"4.4.0"},"reference-count":0,"publisher":"The Journal of Rheumatology","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine cardiovascular pathology in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) vs. population-based controls, and its association with cause of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case-control postmortem study was performed in Australia using the National Coronial Information System (2000-2025). SLE\/RA cases were identified via keyword\/ICD-10 code search. Controls were selected from motor vehicle accident deaths (3:1 ratio). Cardiovascular findings\/histology were extracted from autopsy reports. Associations between SLE\/RA and cardiovascular findings\/outcomes using logistic regression (odds ratios (OR), 95% confidence intervals (CI)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>363 cases (240 RA&amp;123 SLE) and 123 controls of similar age (cases 63y (IQR 53-72), vs. controls 59y (47-73), p=0.166) and sex (female 69% vs. controls 75%, p=0.235) were included. Adjusting for age, sex and BMI, myocardial fibrosis (SLE OR3.66, 95%CI2.00-6.72, p&lt;0.001; RA OR3.96, 95%CI2.37-6.60, p&lt;0.001), myocardial inflammation (SLE OR14.79, 95%CI3.35-65.37, p&lt;0.001; RA OR6.35, 95%CI1.44-28.09, p=0.015) and cardiomegaly (SLE OR5.70, 95%CI2.99-10.86, p&lt;0.001; RA OR3.50, 95%CI2.02-6.08, p&lt;0.001) were more frequent in SLE and RA, as were coronary artery disease (CAD; SLE OR2.46, 95%CI1.34-4.51, p=0.004; RA OR2.56, 95%CI1.54-4.27, p&lt;0.001) and microvascular disease (SLE OR10.28, 95%CI2.28- 46.31; RA OR6.74, 95%CI1.53-29.57, p=0.012). Associations between cardiovascular findings and SLE\/RA status were strongest in under-60s, and persisted after adjusting for CAD. Cardiovascular death was associated with myocardial fibrosis (SLE OR2.35, 95%CI1.02-5.43, p=0.045; RA OR3.62, 95%CI1.81-7.27, p&lt;0.001), cardiomegaly (SLE OR3.77, 95%CI1.71-8.27, p=0.001; RA OR2.52, 95%CI1.44-4.43, p=0.001) and CAD (SLE OR4.12, 95%CI1.76-9.66, p=0.001; RA OR12.71, 95%CI6.59-24.49, p&lt;0.001); and microvascular disease (OR5.26, 95%CI1.40-19.77, p=0.014) and valvular pathology (OR2.68, 95%CI1.11-6.43, p=0.028) in SLE only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This unique dataset identified increased atherosclerotic, inflammatory and fibrotic cardiovascular disease in SLE and RA, particularly in younger individuals. These pathologies were frequently associated with cardiovascular death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.2026-0337","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:20:20Z","timestamp":1792066820000},"page":"jrheum.2026-0337","source":"Crossref","is-referenced-by-count":0,"title":["The spectrum of cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis: a nationwide case-control postmortem study"],"prefix":"10.3899","author":[{"given":"Jessica L","family":"Fairley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Paratz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"McKelvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Daneshvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen","family":"Oon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"La Gerche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2026,10,15]]},"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.2026-0337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:20:21Z","timestamp":1792066821000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.2026-0337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":0,"alternative-id":["10.3899\/jrheum.2026-0337"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.2026-0337","relation":{},"ISSN":["0315-162X","1499-2752","0315-162X"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"},{"value":"0315-162X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,15]]}}}