{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:52:30Z","timestamp":1792068750595,"version":"4.4.0"},"reference-count":0,"publisher":"The Journal of Rheumatology","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated patterns of N-terminal prohormone of n-terminal brain natriuretic peptide (NT-proBNP, a biomarker of cardiac disease) in SLE, and associations with demographic and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the McGill SLE Research Cohort, including yearly serum NTproBNP. We assessed prevalence of baseline elevated NT-proBNP (\u2265133 ng\/L) , and associations with baseline variables: age, sex, race\/ethnicity, age at SLE diagnosis, SLE duration, smoking, and SLE International Collaborating Clinics Damage Index. Patients were classified into four NT-proBNP patterns: abnormal at baseline and remaining abnormal; abnormal and normalizing; normal and becoming abnormal; normal and remaining normal. We compared baseline characteristics across patterns using multivariate logistic regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We studied 294 patients with \u22652 measurements. At baseline, 101 (34.4%) had elevated NT-proBNP. Higher levels were associated with older age at SLE diagnosis, longer SLE duration, cardiovascular damage, pulmonary hypertension, and renal damage. Of 101 individuals with abnormal baseline NT-proBNP, 79 (78.2%) remained abnormal. Of the 193 with normal baseline levels, 30 (15.5%) became abnormal. No patient with a baseline level \u2265350 normalized to &lt;133. High-risk patterns (abnormal-remaining-abnormal and normal-becoming-abnormal) were more likely to have cardiovascular damage (OR 3.90, 95% CI 1.49-12.5, renal damage (OR 2.87, 95% CI 1.61-5.51), and pulmonary hypertension (OR 32.0, 95% CI 4.59-651.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Over one-third of SLE patients had abnormal baseline NT-proBNP; most (78%) remained abnormal. Over 15% of those with an initially normal value became abnormal. Higher levels were associated with age, SLE duration, and organ damage. Levels \u2265350 ng\/L did not normalize over our evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.2026-0384","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:20:20Z","timestamp":1792066820000},"page":"jrheum.2026-0384","source":"Crossref","is-referenced-by-count":0,"title":["Patterns of NT-proBNP in Systemic Lupus Erythematosus"],"prefix":"10.3899","author":[{"given":"Lucia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Vinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Mendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares","family":"Kalache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Pierre","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Sacre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Bernatsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2026,10,15]]},"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.2026-0384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:20:20Z","timestamp":1792066820000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.2026-0384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":0,"alternative-id":["10.3899\/jrheum.2026-0384"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.2026-0384","relation":{},"ISSN":["0315-162X","1499-2752","0315-162X"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"},{"value":"0315-162X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,15]]}}}