{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:35:50Z","timestamp":1789414550878,"version":"build-2803163510"},"reference-count":30,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To investigate the association between Raynaud phenomenon (RP) and coronary microvascular dysfunction, we measured myocardial flow reserve (MFR) using positron emission tomography\/computed tomography (PET\/CT) in patients with primary and secondary RP and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Patients with RP, patient controls, and healthy participants who underwent dynamic rest-stress 82-rubidium PET\/CT were studied. Differences in heart rate\u2013blood pressure product-corrected MFR and clinical predictors of reduced MFR (&lt; 2.0) were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Forty-nine patients with RP (80% female; aged 65 \u00b1 11 yrs; 11 with primary RP, 18 with systemic sclerosis [SSc], and 20 with other autoimmune rheumatic diseases [AIRDs] including 6 with systemic lupus erythematosus, 6 with rheumatoid arthritis, 4 with overlap syndrome, 2 with Sj\u00f6gren syndrome, and 2 with inflammatory arthritis), 49 matched patients without RP or AIRD (78% female; 64 \u00b1 13 yrs), and 14 healthy participants (50% female; 35 \u00b1 5 yrs) were studied. Patients with primary RP, matched patient controls, and healthy participants had comparable MFR. Patients with SSc-RP had significantly reduced MFR (1.62 \u00b1 0.32) compared to matched patient controls (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03, 2.06 \u00b1 0.61) and to healthy participants (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01, 2.22 \u00b1 0.44). In multivariable logistic regression, SSc was an independent predictor of reduced MFR. We identified a correlation between time since AIRD diagnosis and MFR (r = \u20130.30, 95% CI \u20130.63 to \u20130.02,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Our findings suggest that only secondary, not primary, RP is associated with reduced MFR, and that patients with SSc-RP have reduced MFR compared to those with primary RP and patients with other AIRDs. Larger prospective studies are warranted to fully elucidate the prognostic value of MFR in patients with secondary RP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.210040","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T08:22:07Z","timestamp":1626337327000},"page":"1574-1582","source":"Crossref","is-referenced-by-count":21,"title":["Impaired Myocardial Flow Reserve on\n                    <sup>82<\/sup>\n                    Rubidium Positron Emission Tomography\/Computed Tomography in Patients With Systemic Sclerosis"],"prefix":"10.3899","volume":"48","author":[{"given":"Attila","family":"Feher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil E.","family":"Boutagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos K.","family":"Oikonomou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hwa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Sinusas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-9890","authenticated-orcid":false,"given":"Monique","family":"Hinchcliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"2022062307201226000_48.10.1574.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20853"},{"key":"2022062307201226000_48.10.1574.2","first-page":"445","article-title":"Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in northern Sweden","volume":"24","author":"Wallberg-Jonsson","year":"1997","journal-title":"J Rheumatol"},{"key":"2022062307201226000_48.10.1574.3","first-page":"1065","article-title":"Cardiovascular mortality in women with rheumatoid arthritis","volume":"22","author":"Myllykangas-Luosuj\u00e4rvi","year":"1995","journal-title":"J Rheumatol"},{"key":"2022062307201226000_48.10.1574.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035471"},{"key":"2022062307201226000_48.10.1574.5","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009122"},{"key":"2022062307201226000_48.10.1574.6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211448"},{"key":"2022062307201226000_48.10.1574.7","unstructured":"Shah SJ , Mahmood A , Coghlan JG. 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Evaluation using stress cardiovascular magnetic resonance","volume":"228","author":"Mavrogeni","year":"2017","journal-title":"Int J Cardiol"},{"key":"2022062307201226000_48.10.1574.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01829-0"},{"key":"2022062307201226000_48.10.1574.30","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.890"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.210040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T10:21:24Z","timestamp":1655979684000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.210040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,1]]},"published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.3899\/jrheum.210040"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.210040","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-34522\/v1","asserted-by":"object"}]},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]}}}