{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T18:53:02Z","timestamp":1792867982559,"version":"4.5.0"},"reference-count":26,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study analyzes the clinical features of Chinese patients with relapsing polychondritis (RP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of 295 patients with RP at Beijing Tongren Hospital were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of onset was 41.0 \u00b1 15.0 years. The sex ratio was 1:1. Up to 70.5% of the patients had airway involvement during the disease course; among them, the larynx was most commonly affected (82.2%). One-quarter (25.7%) of the patients with laryngeal involvement underwent tracheotomy as a result of progressive dyspnea or acute laryngeal obstruction. Younger age at onset and respiratory symptoms at initial presentation were independent risk factors for tracheotomy in patients with RP with laryngeal involvement. The risk of tracheotomy in patients who presented with respiratory symptoms was 2.35 times higher than that of patients who presented with other symptoms (HR 2.35, 95% CI 1.23\u20134.50,<jats:italic>P<\/jats:italic>= 0.01). The risk of tracheotomy increased by 4.8% for every 1-year decrease in the age at onset (HR 0.95, 95% CI 0.93\u20130.97,<jats:italic>P<\/jats:italic>&lt; 0.001). The incidence of lower respiratory tract infection was much higher in patients with airway involvement than in those without airway involvement. The main cause of death was respiratory failure as a result of airway obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a high prevalence of airway involvement in Chinese patients with RP. Laryngeal involvement is associated with a high risk of death. More attention should be paid to patients with RP with laryngeal involvement who are young at disease onset and present with respiratory symptoms.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.210062","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T12:25:11Z","timestamp":1627820711000},"page":"1876-1882","source":"Crossref","is-referenced-by-count":19,"title":["Characteristics and Clinical Outcomes of 295 Patients With Relapsing Polychondritis"],"prefix":"10.3899","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-9272","authenticated-orcid":false,"given":"Nan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-0705","authenticated-orcid":false,"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"key":"2023010522252294000_48.12.1876.1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/rheumatology\/kez243","article-title":"Fluorodeoxyglucose positron emission tomography\/computed tomography in the diagnosis, assessment of disease activity and therapeutic response in relapsing polychondritis","volume":"59","author":"Sharma","year":"2020","journal-title":"Rheumatology"},{"key":"2023010522252294000_48.12.1876.2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.berh.2016.08.001","article-title":"Relapsing polychondritis: a 2016 update on clinical features, diagnostic tools, treatment and biological drug use","volume":"30","author":"Mathian","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2023010522252294000_48.12.1876.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OARRR.S142892","article-title":"Refractory relapsing polychondritis: challenges and solutions","volume":"10","author":"Lekpa","year":"2018","journal-title":"Open Access Rheumatol"},{"key":"2023010522252294000_48.12.1876.4","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000788"},{"key":"2023010522252294000_48.12.1876.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev240"},{"key":"2023010522252294000_48.12.1876.6","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200401000-00011"},{"key":"2023010522252294000_48.12.1876.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.12.007"},{"key":"2023010522252294000_48.12.1876.8","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1002\/art.39790","article-title":"Relapsing polychondritis can be characterized by three different clinical phenotypes: analysis of a recent series of 142 patients","volume":"68","author":"Dion","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2023010522252294000_48.12.1876.9","doi-asserted-by":"crossref","first-page":"e12837","DOI":"10.1097\/MD.0000000000012837","article-title":"Relapsing polychondritis patients were divided into three subgroups: patients with respiratory involvement (R subgroup), patients with auricular involvement (A subgroup), and overlapping patients with both involvements (O subgroup), and each group had distinctive clinical characteristics","volume":"97","author":"Shimizu","year":"2018","journal-title":"Medicine"},{"key":"2023010522252294000_48.12.1876.10","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/art.41270","article-title":"Defining clinical subgroups in relapsing polychondritis: a prospective observational cohort study","volume":"72","author":"Ferrada","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2023010522252294000_48.12.1876.11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00296-016-3449-8","article-title":"Clinical and prognostic characteristics of 158 cases of relapsing polychondritis in China and review of the literature","volume":"36","author":"Lin","year":"2016","journal-title":"Rheumatol Int"},{"key":"2023010522252294000_48.12.1876.12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7326\/0003-4819-104-1-74","article-title":"Relapsing polychondritis. 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