{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:51:15Z","timestamp":1740153075667,"version":"3.37.3"},"reference-count":12,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The patient experience of gout flares is multidimensional, with several contributing factors including pain intensity, duration, and frequency. There is currently no consistent method for reporting gout flare burden in long-term studies. This study aimed to determine which factors contribute to patient perceptions of treatment efficacy in long-term studies of gout flare prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved face-to-face interviews with people with gout using visual representations of gout flare patterns. Participants were shown different flare scenarios over a hypothetical 6-month treatment period that portrayed varying flare frequency, pain intensity, and flare duration. The participants were asked to indicate and discuss which scenario they believed was most indicative of successful treatment over time. Quantitative data relating to the proportion of participants selecting each scenario were reported using descriptive statistics. A qualitative descriptive approach was used to code and categorize the data from the interview transcripts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty-two people with gout participated in the semistructured interviews. All 3 factors of pain intensity, flare duration, and flare frequency influenced participants\u2019 perception of treatment efficacy. However, a shorter flare duration was the most common indicator of successful treatment, with half of participants (n = 11, 50%) selecting the scenario with a shorter flare duration over those with less painful flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flare duration, flare frequency, and pain severity are all taken into account by patients with gout when considering treatment efficacy over time. Long-term studies of gout should ideally capture all these factors to better represent patients\u2019 experience of treatment success.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.210476","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T12:20:41Z","timestamp":1630498841000},"page":"1871-1875","source":"Crossref","is-referenced-by-count":1,"title":["What Represents Treatment Efficacy in Long-term Studies of Gout Flare Prevention? An Interview Study of People With Gout"],"prefix":"10.3899","volume":"48","author":[{"given":"Jeremy","family":"Holyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Garcia-Guillen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-8479","authenticated-orcid":false,"given":"William J.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-7212","authenticated-orcid":false,"given":"Angelo L.","family":"Gaffo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-962X","authenticated-orcid":false,"given":"Merryn","family":"Gott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-3254","authenticated-orcid":false,"given":"Julia","family":"Slark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-7452","authenticated-orcid":false,"given":"Anne","family":"Horne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-3147","authenticated-orcid":false,"given":"Isabel","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-5627","authenticated-orcid":false,"given":"Sarah","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"2023010522252291000_48.12.1871.1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","article-title":"Gout","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2023010522252291000_48.12.1871.2","unstructured":"Garcia-Guillen A , Stewart S , Su I , Taylor WJ , Gaffo AL , Gott M , . Gout flare severity from the patient perspective: a qualitative interview study. Arthritis Care Res 2020 (Epub ahead of print)."},{"key":"2023010522252291000_48.12.1871.3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.semarthrit.2020.06.001","article-title":"The experience of a gout flare: a meta-synthesis of qualitative studies","volume":"50","author":"Stewart","year":"2020","journal-title":"Semin Arthritis Rheum"},{"key":"2023010522252291000_48.12.1871.4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090370"},{"key":"2023010522252291000_48.12.1871.5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090371"},{"key":"2023010522252291000_48.12.1871.6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s41927-019-0075-6","article-title":"The challenges of gout flare reporting : mapping flares during a randomized controlled trial","volume":"3","author":"Teoh","year":"2019","journal-title":"BMC Rheumatology"},{"key":"2023010522252291000_48.12.1871.7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.semarthrit.2019.11.002","article-title":"How flare prevention outcomes are reported in gout studies: a systematic review and content analysis of randomized controlled trials","volume":"50","author":"Stewart","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"2023010522252291000_48.12.1871.8","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170911"},{"key":"2023010522252291000_48.12.1871.9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/rheumatology\/keaa413","article-title":"Which factors predict discordance between a patient and physician on a gout flare?","volume":"60","author":"Jagpal","year":"2020","journal-title":"Rheumatology"},{"key":"2023010522252291000_48.12.1871.10","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/art.39254","article-title":"2015 Gout Classification Criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"67","author":"Neogi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2023010522252291000_48.12.1871.11","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"2023010522252291000_48.12.1871.12","doi-asserted-by":"publisher","DOI":"10.3399\/bjgpopen20X101003"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.210476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T06:36:01Z","timestamp":1672986961000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.210476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":12,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,1]]},"published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.3899\/jrheum.210476"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.210476","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"type":"print","value":"0315-162X"},{"type":"electronic","value":"1499-2752"}],"subject":[],"published":{"date-parts":[[2021,9,1]]}}}