{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:11:14Z","timestamp":1792757474477,"version":"4.5.0"},"reference-count":40,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall female\/male ratio was 8.2:1. Female\/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La\/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.210794","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:20:26Z","timestamp":1636982426000},"page":"176-185","source":"Crossref","is-referenced-by-count":43,"title":["Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology"],"prefix":"10.3899","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5169-3511","authenticated-orcid":false,"given":"Rossella","family":"De Angelis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilia","family":"Giuggioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-800X","authenticated-orcid":false,"given":"Gianluigi","family":"Bajocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-315X","authenticated-orcid":false,"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-1282","authenticated-orcid":false,"given":"Giovanni","family":"Zanframundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Foti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-4462","authenticated-orcid":false,"given":"Fabio","family":"Cacciapaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-3589","authenticated-orcid":false,"given":"Giovanna","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-6102","authenticated-orcid":false,"given":"Alarico","family":"Ariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-8093","authenticated-orcid":false,"given":"Edoardo","family":"Rosato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-6475","authenticated-orcid":false,"given":"Serena","family":"Guiducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Girelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Riccieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zanatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-447X","authenticated-orcid":false,"given":"Silvia","family":"Bosello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-7120","authenticated-orcid":false,"given":"Ilaria","family":"Cavazzana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-1273","authenticated-orcid":false,"given":"Francesca","family":"Ingegnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-1336","authenticated-orcid":false,"given":"Maria De","family":"Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Murdaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-0133","authenticated-orcid":false,"given":"Giuseppina","family":"Abignano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Della Rossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Caminiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Iuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-8520","authenticated-orcid":false,"given":"Gianluca","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-5328","authenticated-orcid":false,"given":"Ennio","family":"Lubrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"De Andres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-7673","authenticated-orcid":false,"given":"Alessandro","family":"Giollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Saracco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Agnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-7982","authenticated-orcid":false,"given":"Federica","family":"Lumetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Spinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-0785","authenticated-orcid":false,"given":"Luca","family":"Magnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-3794","authenticated-orcid":false,"given":"Corrado","family":"Campochiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5306-7714","authenticated-orcid":false,"given":"Giacomo","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-8514","authenticated-orcid":false,"given":"Veronica","family":"Codullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-5528","authenticated-orcid":false,"given":"Elisa","family":"Visalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Masini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bellando-Randone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Pigatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dall\u2019Ara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Lazzaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-1767","authenticated-orcid":false,"given":"Elena","family":"Generali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Mennillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-4505","authenticated-orcid":false,"given":"Simone","family":"Barsotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa Pagano","family":"Mariano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-1913","authenticated-orcid":false,"given":"Federica","family":"Furini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Vultaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Lisa","family":"Peroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Risa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Rozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-451X","authenticated-orcid":false,"given":"Anna","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Carrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Landolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-0271","authenticated-orcid":false,"given":"Carlo Alberto","family":"Scir\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerolamo","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-6649","authenticated-orcid":false,"given":"Gian Domenico","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-5773","authenticated-orcid":false,"given":"Marcello","family":"Govoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-1110","authenticated-orcid":false,"given":"Salvatore","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-3927","authenticated-orcid":false,"given":"Franco","family":"Cozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-4983","authenticated-orcid":false,"given":"Andrea","family":"Doria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-5344","authenticated-orcid":false,"given":"Florenzo","family":"Iannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-5133","authenticated-orcid":false,"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-3161","authenticated-orcid":false,"given":"Marco","family":"Matucci-Cerinic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-5817","authenticated-orcid":false,"given":"Clodoveo","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Systemic sclerosis PRogression INvestiGation group (SPRING)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"2022102909150398000_49.2.176.1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5301\/jsrd.5000249","article-title":"Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities","volume":"2","author":"Varga","year":"2017","journal-title":"J Scleroderma Relat Disord"},{"key":"2022102909150398000_49.2.176.2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/2397198320924873","article-title":"Overall mortality","volume":"6","author":"Moore","year":"2021","journal-title":"J Scleroderma Relat Disord"},{"key":"2022102909150398000_49.2.176.3","doi-asserted-by":"crossref","first-page":"102494","DOI":"10.1016\/j.autrev.2020.102494","article-title":"Gender-related differences in systemic sclerosis","volume":"19","author":"Hughes","year":"2020","journal-title":"Autoimmunity Rev"},{"key":"2022102909150398000_49.2.176.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.9.910"},{"key":"2022102909150398000_49.2.176.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2007.07.010"},{"key":"2022102909150398000_49.2.176.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.06.002"},{"key":"2022102909150398000_49.2.176.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.24284"},{"key":"2022102909150398000_49.2.176.8","first-page":"S10","article-title":"Sex and time to diagnosis in systemic sclerosis: an updated analysis of 1,129 patients from the Canadian scleroderma research group registry","volume":"32","author":"Delisle","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"2022102909150398000_49.2.176.9","first-page":"89","article-title":"Clinical and epidemiological differences between men and women with systemic sclerosis: a study in a Spanish systemic sclerosis cohort and literature review","volume":"35","author":"Freire","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"2022102909150398000_49.2.176.10","first-page":"68","article-title":"Gender differences in early systemic sclerosis patients: a report from the EULAR scleroderma trials and research group (EUSTAR) database","volume":"36","author":"Carreira","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"2022102909150398000_49.2.176.11","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140006"},{"key":"2022102909150398000_49.2.176.12","first-page":"177","article-title":"Gender differences in systemic sclerosis: relationship to clinical features, serological status and outcomes","volume":"1","author":"Peoples","year":"2016","journal-title":"J Scleroderma Relat Disord"},{"key":"2022102909150398000_49.2.176.13","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206386"},{"key":"2022102909150398000_49.2.176.14","first-page":"40","article-title":"Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinic-serological features of scleroderma spectrum","volume":"38","author":"Ferri","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"2022102909150398000_49.2.176.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"2022102909150398000_49.2.176.16","doi-asserted-by":"crossref","first-page":"875","DOI":"10.17219\/acem\/64334","article-title":"Systemic sclerosis sine scleroderma","volume":"26","author":"Kucharcz","year":"2017","journal-title":"Adv Clin Exp Med"},{"key":"2022102909150398000_49.2.176.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00194909"},{"key":"2022102909150398000_49.2.176.18","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00004"},{"key":"2022102909150398000_49.2.176.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.029"},{"key":"2022102909150398000_49.2.176.20","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140236"},{"key":"2022102909150398000_49.2.176.21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017551"},{"key":"2022102909150398000_49.2.176.22","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20336"},{"key":"2022102909150398000_49.2.176.23","first-page":"46","article-title":"Clinical characteristics of systemic sclerosis patients with digital ulcers in China","volume":"31","author":"Xu","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"2022102909150398000_49.2.176.24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/CH-141809","article-title":"Prediction risk chart for scleroderma: a composite predictive model based on capillaroscopic, demographic and clinical-serological parameters","volume":"59","author":"Manfredi","year":"2015","journal-title":"Clin Hemorheol Microcirc"},{"key":"2022102909150398000_49.2.176.25","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120667"},{"key":"2022102909150398000_49.2.176.26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/art.40377","article-title":"Defining a unified vascular phenotype in systemic sclerosis","volume":"70","author":"Allanore","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2022102909150398000_49.2.176.27","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1093\/rheumatology\/kez494","article-title":"Cardiac magnetic resonance predicts ventricular arrhythmias in scleroderma: the Scleroderma Arrhythmia Clinical Utility Study (SAnCtUS)","volume":"59","author":"Mavrogeni","year":"2020","journal-title":"Rheumatology"},{"key":"2022102909150398000_49.2.176.28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13075-016-0933-1","article-title":"Sex disparities in systemic sclerosis-associated pulmonary arterial hypertension: a cohort study","volume":"18","author":"Pasarikovski","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2022102909150398000_49.2.176.29","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.103382"},{"key":"2022102909150398000_49.2.176.30","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834b8975"},{"key":"2022102909150398000_49.2.176.31","doi-asserted-by":"crossref","first-page":"e013405","DOI":"10.1161\/JAHA.119.013405","article-title":"Cardiovascular manifestations of systemic sclerosis: a Danish nationwide cohort study","volume":"8","author":"Butt","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2022102909150398000_49.2.176.32","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket377"},{"key":"2022102909150398000_49.2.176.33","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00002915"},{"key":"2022102909150398000_49.2.176.34","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0102-2017"},{"key":"2022102909150398000_49.2.176.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2014.12.005"},{"key":"2022102909150398000_49.2.176.36","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215777"},{"key":"2022102909150398000_49.2.176.37","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214764"},{"key":"2022102909150398000_49.2.176.38","doi-asserted-by":"publisher","DOI":"10.1186\/ar3495"},{"key":"2022102909150398000_49.2.176.39","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215797"},{"key":"2022102909150398000_49.2.176.40","first-page":"1826","article-title":"Cutaneous and serologic subsets in systemic sclerosis","volume":"18","author":"Ferri","year":"1991","journal-title":"J Rheumatol"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.210794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T16:15:27Z","timestamp":1667060127000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.210794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,1]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.3899\/jrheum.210794"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.210794","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,15]]}}}