{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:17:50Z","timestamp":1768623470822,"version":"3.49.0"},"reference-count":18,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe characteristics and coronavirus disease 2019 (COVID-19) clinical outcomes of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ulcerative colitis (UC) receiving systemic therapies vs the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This descriptive retrospective cohort study used data from the United States Optum deidentified COVID-19 electronic health record dataset (2007\u20132020). Adults with COVID-19 were stratified into 3 disease cohorts (patients with RA, PsA, or UC who had received systemic therapy) and a comparator cohort not meeting these criteria. Incidence proportions of hospitalization and clinical manifestations of interest were calculated. Using logistic regression analyses, risk of endpoints was estimated, adjusting for demographics and demographics plus comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis (February 1 to December 9, 2020) included 315,101 patients with COVID-19. Adjusting for demographics, COVID-19 patients with RA (n = 2306) had an increased risk of hospitalization (OR 1.54, 95% CI 1.39\u20131.70) and in-hospital death (OR 1.61, 95% CI 1.30\u20132.00) compared with the comparator cohort (n = 311,563). The increased risk was also observed when adjusted for demographics plus comorbidities (hospitalization OR 1.25, 95% CI 1.13\u20131.39 and in-hospital death OR 1.35, 95% CI 1.09\u20131.68]). The risk of hospitalization was lower in COVID-19 patients with RA receiving tumor necrosis factor inhibitors (TNFi) vs non-TNFi biologics (OR 0.32, 95% CI 0.20\u20130.53) and the comparator cohort (OR 0.77, 95% CI 0.51\u20131.17). The risk of hospitalization due to COVID-19 was similar between patients receiving tofacitinib and the comparator cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with the comparator cohort, patients with RA were at a higher risk of more severe or critical COVID-19 and, except for non-TNFi biologics, systemic therapies did not further increase the risk. (ENCePP; registration no. EU PAS 35384)<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.210888","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:22:18Z","timestamp":1636982538000},"page":"320-329","source":"Crossref","is-referenced-by-count":28,"title":["Characteristics, Comorbidities, and Outcomes of SARS-CoV-2 Infection in Patients With Autoimmune Conditions Treated With Systemic Therapies: A Population-based Study"],"prefix":"10.3899","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-8976","authenticated-orcid":false,"given":"Jeffrey R.","family":"Curtis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-0012","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-1723","authenticated-orcid":false,"given":"David T.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-091X","authenticated-orcid":false,"given":"Walter","family":"Reinisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-4094","authenticated-orcid":false,"given":"Jinoos","family":"Yazdany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-3418","authenticated-orcid":false,"given":"Philip C.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6367-7540","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8712-2251","authenticated-orcid":false,"given":"Birgitta","family":"Benda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-708X","authenticated-orcid":false,"given":"Ann","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-2117","authenticated-orcid":false,"given":"Jamie","family":"Geier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"2022062202300634000_49.3.320.1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes305"},{"key":"2022062202300634000_49.3.320.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.12.013"},{"key":"2022062202300634000_49.3.320.3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/14740338.2016.1240783","article-title":"Risk of infections using anti-TNF agents in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: a systematic review and meta-analysis","volume":"15","author":"Minozzi","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"2022062202300634000_49.3.320.4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/art.41734","article-title":"American College of Rheumatology guidance for COVID-19 vaccination in patients with rheumatic and musculoskeletal diseases: version 1","volume":"73","author":"Curtis","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"2022062202300634000_49.3.320.5","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2014.0038"},{"key":"2022062202300634000_49.3.320.6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219498"},{"key":"2022062202300634000_49.3.320.7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217871"},{"key":"2022062202300634000_49.3.320.8","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/art.41456","article-title":"COVID-19 in patients with inflammatory arthritis: a prospective study on the effects of comorbidities and disease-modifying antirheumatic drugs on clinical outcomes","volume":"72","author":"Haberman","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2022062202300634000_49.3.320.9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-eular.1181"},{"key":"2022062202300634000_49.3.320.10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-eular.1289"},{"key":"2022062202300634000_49.3.320.11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/acr2.11252","article-title":"Gout, rheumatoid arthritis, and the risk of death related to coronavirus disease 2019: an analysis of the UK Biobank","volume":"3","author":"Topless","year":"2021","journal-title":"ACR Open Rheumatol"},{"key":"2022062202300634000_49.3.320.12","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1093\/ibd\/izaa170","article-title":"The incidence and outcomes of COVID-19 in IBD patients: a rapid review and meta-analysis","volume":"26","author":"Aziz","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2022062202300634000_49.3.320.13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.032"},{"key":"2022062202300634000_49.3.320.14","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1053\/j.gastro.2020.06.003","article-title":"Risk of severe coronavirus disease 2019 in patients with inflammatory bowel disease in the United States: a multicenter research network study","volume":"159","author":"Singh","year":"2020","journal-title":"Gastroenterology"},{"key":"2022062202300634000_49.3.320.15","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-eular.2252"},{"key":"2022062202300634000_49.3.320.16","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa303"},{"key":"2022062202300634000_49.3.320.17","unstructured":"Kluberg S. Validation of claims-based algorithms to identify hospitalized COVID-19 events within the FDA Sentinel system. [Internet. Accessed November 16, 2021]. Available from: https:\/\/www.sentinelinitiative.org\/sites\/default\/files\/communications\/publications-presentations\/Validation_of_claims_based_algorithms.pdf"},{"key":"2022062202300634000_49.3.320.18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/oby.23076","article-title":"BMI as a risk factor for clinical outcomes in patients hospitalized with COVID-19 in New York","volume":"29","author":"Kim","year":"2021","journal-title":"Obesity"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.210888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T09:32:37Z","timestamp":1655890357000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.210888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,1]]},"published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.3899\/jrheum.210888"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.210888","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,15]]}}}