{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:44:50Z","timestamp":1790163890933,"version":"4.1.0"},"reference-count":13,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether perifollicular hypopigmentation in systemic sclerosis (SSc) is associated with demographics, distinct clinical features, and autoantibody profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SSc were prospectively enrolled, with a standardized data form used to collect anatomic distribution of perifollicular hypopigmentation. Associations between hypopigmentation and features of SSc were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 179 adult patients with SSc, 36 (20%) patients had perifollicular hypopigmentation. Of these 36 patients, 94% (n = 34) were female and 33% (n = 12) had limited cutaneous SSc. In univariable logistic regression, Black race (odds ratio [OR] 15.63, 95% CI 6.6\u201337.20,<jats:italic>P<\/jats:italic>&lt; 0.001), diffuse cutaneous SSc (dcSSc; OR 4.62, 95% CI 2.11\u201310.09,<jats:italic>P<\/jats:italic>&lt; 0.001), higher maximum modified Rodnan skin score (mRSS; OR 1.05, 95% CI 1.02\u20131.08,<jats:italic>P<\/jats:italic>= 0.003), myopathy (OR 3.92, 95% CI 1.80\u20138.57,<jats:italic>P<\/jats:italic>&lt; 0.001), pulmonary fibrosis (OR 2.69, 95% CI 1.20-6.02,<jats:italic>P<\/jats:italic>= 0.02), lower minimum forced vital capacity % predicted (OR 0.96, 95% CI 0.94\u20130.99,<jats:italic>P<\/jats:italic>= 0.001), and lower minimum diffusing capacity for carbon monoxide % predicted (OR 0.97, 95% CI 0.95\u20130.99,<jats:italic>P<\/jats:italic>= 0.009) were associated with hypopigmentation. Anticentromere antibodies inversely associated with hypopigmentation (OR 0.24, 95% CI 0.07\u20130.86,<jats:italic>P<\/jats:italic>= 0.03). After adjusting for age, race, and disease duration, dcSSc (OR 4.28, 95% CI 1.46-12.53,<jats:italic>P<\/jats:italic>= 0.008) and increased mRSS (OR 1.07, 95% CI 1.02\u20131.12,<jats:italic>P<\/jats:italic>= 0.009) were significantly associated with hypopigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perifollicular hypopigmentation is observed in a subset of patients with SSc and associated with diffuse subtype. Larger prospective studies determining whether perifollicular hypopigmentation precedes end-organ involvement and whether specific patterns associate with internal organ involvement are needed.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.210983","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T13:25:38Z","timestamp":1644931538000},"page":"475-481","source":"Crossref","is-referenced-by-count":6,"title":["Perifollicular Hypopigmentation in Systemic Sclerosis: Associations With Clinical Features and Internal Organ Involvement"],"prefix":"10.3899","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-4910","authenticated-orcid":false,"given":"Melody P.","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-8392","authenticated-orcid":false,"given":"Christopher A.","family":"Mecoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-6620","authenticated-orcid":false,"given":"Jamie","family":"Perin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-8940","authenticated-orcid":false,"given":"Zsuzsanna H.","family":"McMahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"2022062202350618000_49.5.475.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"2022062202350618000_49.5.475.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker518"},{"key":"2022062202350618000_49.5.475.3","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22498"},{"key":"2022062202350618000_49.5.475.4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090697"},{"key":"2022062202350618000_49.5.475.5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5070\/D31368X3WX","article-title":"Pseudovitiligo in systemic sclerosis","volume":"11","author":"Rai","year":"2005","journal-title":"Dermatol Online 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