{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:22:51Z","timestamp":1793830971128,"version":"4.6.1"},"reference-count":49,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To investigate demographic, lifestyle, and serologic risk factors for isolated rheumatoid arthritis (RA)\u2013associated bronchiectasis (RA-BR) that is not a result of interstitial lung disease (ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>We performed a case-control study using patients with RA from the Mass General Brigham Biobank. We reviewed the records of all patients with RA meeting the 2010 American College of Rheumatology\/European Alliance of Associations for Rheumatology criteria with computed tomography (CT) chest imaging to identify RA-BR cases and controls with RA and RA-related lung disease. For each patient, the CT chest imaging that was performed closest to enrollment was independently reviewed by 2 radiologists for the presence of RA-related lung diseases. Cases had clinical and radiologic evidence of RA-BR without interstitial lung abnormalities on imaging. Controls had RA and no evidence of bronchiectasis or ILD. We examined the associations between demographic, lifestyle, and serologic factors with RA-BR using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      We identified 57 cases of isolated RA-BR and 360 RA controls without RA-related lung disease. In multivariable models, RA-BR was associated with older age at RA onset (OR 1.37 per 10 years, 95% CI 1.02\u20131.82), lower BMI at RA diagnosis (OR 0.94 per kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI 0.89\u20130.99), seropositive RA (OR 3.96, 95% CI 1.84\u20138.53), positive rheumatoid factor (OR 4.40, 95% CI 2.14\u20139.07), and positive anticyclic citrullinated peptide (OR 3.47, 95% CI 1.65\u20137.31). Higher titers of RA-related autoantibodies were associated with higher odds of RA-BR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Seropositivity, older age at RA diagnosis, and lower BMI at RA onset were associated with isolated bronchiectasis in RA that was not a result of ILD. These findings expand the list of potential risk factors for RA-BR and suggest a pathogenic link between airway inflammation and RA-related autoantibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.211242","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T08:25:34Z","timestamp":1647332734000},"page":"672-679","source":"Crossref","is-referenced-by-count":18,"title":["Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis (RA)\u2013associated Bronchiectasis: Role of RA-related Autoantibodies"],"prefix":"10.3899","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-5448","authenticated-orcid":false,"given":"Gregory","family":"McDermott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"Gagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Prisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Zaccardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily W.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Masto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-3134","authenticated-orcid":false,"given":"Vanessa L.","family":"Kronzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Shadick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Dellaripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy J.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-4618","authenticated-orcid":false,"given":"Jeffrey A.","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"2022070105203842000_49.7.672.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012519"},{"key":"2022070105203842000_49.7.672.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0776"},{"key":"2022070105203842000_49.7.672.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.6.689"},{"key":"2022070105203842000_49.7.672.4","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.chest.2016.12.024","article-title":"Bronchiectasis rheumatoid overlap syndrome is an independent risk factor for mortality in patients with bronchiectasis: a multicenter cohort study","volume":"151","author":"De Soyza","year":"2017","journal-title":"Chest"},{"key":"2022070105203842000_49.7.672.5","doi-asserted-by":"crossref","first-page":"e110066","DOI":"10.1371\/journal.pone.0110066","article-title":"Poor survival in rheumatoid arthritis associated with bronchiectasis: a family-based cohort study","volume":"9","author":"Pu\u00e9chal","year":"2014","journal-title":"PLoS One"},{"key":"2022070105203842000_49.7.672.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.06.020"},{"key":"2022070105203842000_49.7.672.7","doi-asserted-by":"crossref","first-page":"1479973121994565","DOI":"10.1177\/1479973121994565","article-title":"A causal relationship between rheumatoid arthritis and bronchiectasis? 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