{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:22Z","timestamp":1790659702839,"version":"4.1.0"},"reference-count":28,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe psoriatic arthritis (PsA) flares and their effect on patient-reported outcomes (PROs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross-sectional surveys of rheumatologists\/dermatologists and their patients with PsA were conducted in France, Germany, Italy, Spain, the United Kingdom, and the United States, capturing data on physician-reported patient flare status, demographics, PsA severity, and clinical outcomes. Patient-completed surveys captured data on PROs: 5-level EuroQol 5-dimension, Work Productivity and Activity Impairment questionnaire, Health Assessment Questionnaire\u2013Disability Index, and 12-item Psoriatic Arthritis Impact of Disease questionnaire. Patients were compared by flare status using parametric and nonparametric tests. Multivariate regression was used to identify flare associations. Multivariate logistic regression adjusted for patient demographics and physician specialty assessed the effect of flare status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2238 patients (586 from the US, 1652 from Europe) managed by 572 physicians, physician-reported flare was present for 168 patients (7.5%), and self-reported flare was present for 95 patients (10% of available data). Mean (SD) flare count over 12 months was 2.2 (4.9), lasting on average 16.4 (16.2) days. Flare status was linked to worse PROs. Patients who had not flared in the last 12 months or had never flared had a higher quality of life, lower overall work impairment, and a lower degree of disability compared with patients who were currently experiencing a flare (all;<jats:italic>P<\/jats:italic>&lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Actively experiencing a flare adversely affected QOL, disability, and work productivity. PsA flares should be routinely assessed and managed in clinical care.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.211302","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T12:20:14Z","timestamp":1660566014000},"page":"76-83","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Physician-Defined Flares on Quality of Life and Work Impairment: An International Survey of 2238 Patients With Psoriatic Arthritis"],"prefix":"10.3899","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-8567","authenticated-orcid":false,"given":"Ana-Maria","family":"Orbai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Tillett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Grieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-5711","authenticated-orcid":false,"given":"Elizabeth A.","family":"Holdsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya D.","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-310X","authenticated-orcid":false,"given":"Laure","family":"Gossec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"2023121810351098000_50.1.76.1","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.12688\/f1000research.9592.1","article-title":"Recent advances in understanding and managing psoriatic arthritis","volume":"5","author":"Gladman","year":"2016","journal-title":"F1000Res"},{"key":"2023121810351098000_50.1.76.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.004"},{"key":"2023121810351098000_50.1.76.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker216"},{"key":"2023121810351098000_50.1.76.4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/1744666X.2018.1468252","article-title":"Quality of life in psoriatic arthritis","volume":"14","author":"Gudu","year":"2018","journal-title":"Expert Rev Clin Immunol"},{"key":"2023121810351098000_50.1.76.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev009"},{"key":"2023121810351098000_50.1.76.6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s40744-019-00171-w","article-title":"Sustained very low disease activity and remission in psoriatic arthritis patients","volume":"6","author":"Lubrano","year":"2019","journal-title":"Rheumatol Ther"},{"key":"2023121810351098000_50.1.76.7","doi-asserted-by":"crossref","first-page":"rkz022","DOI":"10.1093\/rap\/rkz022","article-title":"Diagnosis and initial management in psoriatic arthritis: a qualitative study with patients","volume":"3","author":"Dures","year":"2019","journal-title":"Rheumatology Adv Pract"},{"key":"2023121810351098000_50.1.76.8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu264"},{"key":"2023121810351098000_50.1.76.9","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802457040"},{"key":"2023121810351098000_50.1.76.10","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-94"},{"key":"2023121810351098000_50.1.76.11","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"2023121810351098000_50.1.76.12","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20620"},{"key":"2023121810351098000_50.1.76.13","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181077"},{"key":"2023121810351098000_50.1.76.14","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"2023121810351098000_50.1.76.15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem Med"},{"key":"2023121810351098000_50.1.76.16","unstructured":"StataCorp . 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