{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:19:28Z","timestamp":1774984768715,"version":"3.50.1"},"reference-count":29,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess test-retest reliability, construct validity, known groups discrimination, and responsiveness of the Assessment of the SpondyloArthritis international Society Health Index (ASAS HI) to evaluate functioning, disability, and health in patients with radiographic axial spondyloarthritis (r-axSpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were generated from 2 randomized, placebo-controlled, active-controlled phase III ixekizumab studies (COAST-V, N = 341; COAST-W, N = 316). Assessments included the following: test-retest reliability (ie, intraclass correlation coefficients [ICCs] between ASAS HI scores at screening and baseline), construct validity (ie, Spearman correlation with standard r-axSpA outcome measures), known groups discrimination (ie, 1-way ANOVA comparing the ASAS HI with different disease activity categories, measured by the Ankylosing Spondylitis Disease Activity Score [ASDAS]), and responsiveness (ie, Spearman correlation between changes in the ASAS HI and changes in the Bath Ankylosing Spondylitis Functional Index [BASFI], the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], the ASDAS, and the Patient Global Assessment [PtGA] as well as ANOVA comparing changes in the ASAS HI with various responder categories).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ICC for test-retest reliability was 0.78 for COAST-V and 0.76 for COAST-W, indicating adequate agreement. Moderate-to-large correlations (<jats:italic>r<\/jats:italic>= 0.40-0.61) were observed between the ASAS HI and the BASDAI. Statistically significant differences (all<jats:italic>P<\/jats:italic>&lt; 0.001) between mean ASAS HI scores were observed for subgroups based on ASDAS-defined disease activity categories at baseline and week 16. Moderate-to-large correlations existed between changes in the ASAS HI and the BASFI, BASDAI, ASDAS, and PtGA from baseline to week 16. The ASAS HI differentiated statistically (<jats:italic>P<\/jats:italic>&lt; 0.001) between ASAS, BASDAI, and ASDAS response groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ASAS HI demonstrated reliability, construct validity, known groups discrimination, and responsiveness in adults with r-axSpA in 2 clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.220244","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T13:43:07Z","timestamp":1675258987000},"page":"754-762","source":"Crossref","is-referenced-by-count":7,"title":["Clinimetric Validation of the Assessment of Spondyloarthritis International Society Health Index in Patients With Radiographic Axial Spondyloarthritis in Ixekizumab Trials"],"prefix":"10.3899","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-4497","authenticated-orcid":false,"given":"Uta","family":"Kiltz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9sir\u00e9e","family":"van der Heijde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Boonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianne S.","family":"Gensler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa Hunter","family":"Gibble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Carlier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"2023060503351750000_50.6.754.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"2023060503351750000_50.6.754.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38140"},{"key":"2023060503351750000_50.6.754.3","doi-asserted-by":"crossref","first-page":"e0126105","DOI":"10.1371\/journal.pone.0126105","article-title":"The cost of ankylosing spondylitis in the UK using linked routine and patient-reported survey data","volume":"10","author":"Cooksey","year":"2015","journal-title":"PLoS One"},{"key":"2023060503351750000_50.6.754.4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.23304","article-title":"Social role participation and satisfaction with life: a study among patients with ankylosing spondylitis and population controls","volume":"70","author":"van Genderen","year":"2018","journal-title":"Arthritis Care Res"},{"key":"2023060503351750000_50.6.754.5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203967"},{"key":"2023060503351750000_50.6.754.6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104117"},{"key":"2023060503351750000_50.6.754.7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212076"},{"key":"2023060503351750000_50.6.754.8","first-page":"2225","article-title":"Preliminary core sets for endpoints in ankylosing spondylitis. Assessments in Ankylosing Spondylitis Working Group","volume":"24","author":"van der Heijde","year":"1997","journal-title":"J Rheumatol"},{"key":"2023060503351750000_50.6.754.9","first-page":"951","article-title":"Selection of instruments in the core set for DC-ART, SMARD, physical therapy, and clinical record keeping in ankylosing spondylitis. Progress report of the ASAS Working Group. Assessments in Ankylosing Spondylitis","volume":"26","author":"van der Heijde","year":"1999","journal-title":"J Rheumatol"},{"key":"2023060503351750000_50.6.754.10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00296-016-3642-9","article-title":"Defining functioning categories in axial Spondyloarthritis: the role of the ASAS Health Index","volume":"37","author":"Di Carlo","year":"2017","journal-title":"Rheumatol Int"},{"key":"2023060503351750000_50.6.754.11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/art.40753","article-title":"Efficacy and safety of ixekizumab in the treatment of radiographic axial spondyloarthritis: sixteen-week results from a phase III randomized, double-blind, placebo-controlled trial in patients with prior inadequate response to or intolerance of tumor necrosis factor inhibitors","volume":"71","author":"Deodhar","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2023060503351750000_50.6.754.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31946-9"},{"key":"2023060503351750000_50.6.754.13","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S100940"},{"key":"2023060503351750000_50.6.754.14","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett","year":"1994","journal-title":"J Rheumatol"},{"key":"2023060503351750000_50.6.754.15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"2023060503351750000_50.6.754.16","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.130625"},{"key":"2023060503351750000_50.6.754.17","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138594"},{"key":"2023060503351750000_50.6.754.18","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20575"},{"key":"2023060503351750000_50.6.754.19","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath AS Functional Index (BASFI)","volume":"21","author":"Calin","year":"1994","journal-title":"J Rheumatol"},{"key":"2023060503351750000_50.6.754.20","doi-asserted-by":"publisher","DOI":"10.1002\/hec.3564"},{"key":"2023060503351750000_50.6.754.21","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200012150-00008"},{"key":"2023060503351750000_50.6.754.22","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151244"},{"key":"2023060503351750000_50.6.754.23","unstructured":"Nunnally JC , Bernstein IH. Psychometric theory. 3rd ed. New York, NY: McGraw-Hill; 1994."},{"key":"2023060503351750000_50.6.754.24","unstructured":"Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988."},{"key":"2023060503351750000_50.6.754.25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12955-016-0463-1","article-title":"Clinimetric properties of the ASAS health index in a cohort of Italian patients with axial spondyloarthritis","volume":"14","author":"Di Carlo","year":"2016","journal-title":"Health Qual Life Outcomes"},{"key":"2023060503351750000_50.6.754.26","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200025"},{"key":"2023060503351750000_50.6.754.27","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200708"},{"key":"2023060503351750000_50.6.754.28","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1093\/rheumatology\/keab653","article-title":"Development of an environmental contextual factor item set relevant to global functioning and health in patients with axial spondyloarthritis","volume":"61","author":"Kiltz","year":"2022","journal-title":"Rheumatology"},{"key":"2023060503351750000_50.6.754.29","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219585"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.220244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T10:37:18Z","timestamp":1685961438000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.220244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.3899\/jrheum.220244"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.220244","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}