{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:25:09Z","timestamp":1783398309428,"version":"3.54.6"},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA), and modified versions thereof, in a North American cohort of patients with enthesitis-related arthritis (ERA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized the Childhood Arthritis and Rheumatology Research Alliance Registry database ERA cohort to validate the JSpADA and its modifications (JSpADA6-no Schober, no C-reactive protein [CRP]\/erythrocyte sedimentation rate [ESR]; JSpADA7-no Schober; and JSpADA7-no CRP\/ESR) using the Outcome Measures in Rheumatology principles of face validity, discriminative validity, and responsiveness to change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 51 subjects (64 visits) with complete JSpADA data with a mean age of 13.7 years and disease duration of 30.9 months. Subjects were predominantly White (84.3%), and 56.9% were male and 50% were HLA-B27 positive. The JSpADA showed high correlation with the clinical 10-joint Juvenile Arthritis Disease Activity Score (cJADAS10;<jats:italic>r<\/jats:italic>= 0.81), moderate-to-high correlation with physician global assessment (PGA;<jats:italic>r<\/jats:italic>= 0.69), and low-to-fair correlation with Childhood Health Assessment Questionnaire (CHAQ;<jats:italic>r<\/jats:italic>= 0.22). The modifications of the JSpADA (JSpADA7-no Schober; JSpADA7-no CRP\/ESR; and JSpADA6-no Schober, no CRP\/ESR) performed similarly with high correlation with cJADAS10 (<jats:italic>r<\/jats:italic>= 0.81, 0.79, and 0.80, respectively), moderate-to-high correlation with PGA (<jats:italic>r<\/jats:italic>= 0.65, 0.67, 0.64, respectively), and low-to-fair correlation with CHAQ (<jats:italic>r<\/jats:italic>= 0.35, 0.34, 0.39, respectively). All modified versions of JSpADA had good responsiveness to change. All versions of JSpADA had excellent discriminative validity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose the term<jats:italic>modified JSpADA<\/jats:italic>for the modification of JSpADA with 6 elements (JSpADA6-no Schober, no CRP\/ESR). This shorter disease activity index may improve implementation of JSpADA in both clinical practice and research trials.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.220509","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T12:16:30Z","timestamp":1667304990000},"page":"532-537","source":"Crossref","is-referenced-by-count":16,"title":["Modified Juvenile Spondyloarthritis Disease Activity Index in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry"],"prefix":"10.3899","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-4170","authenticated-orcid":false,"given":"Hemalatha","family":"Srinivasalu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-7065","authenticated-orcid":false,"given":"Erin Brennan","family":"Treemarcki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-4640","authenticated-orcid":false,"given":"Dax G.","family":"Rumsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-0443","authenticated-orcid":false,"given":"Pamela F.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-4575","authenticated-orcid":false,"given":"Robert A.","family":"Colbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2023122109250663000_50.4.532.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.03.006"},{"key":"2023122109250663000_50.4.532.2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150092"},{"key":"2023122109250663000_50.4.532.3","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120642"},{"key":"2023122109250663000_50.4.532.4","first-page":"1122","article-title":"Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study","volume":"32","author":"Selvaag","year":"2005","journal-title":"J Rheumatol"},{"key":"2023122109250663000_50.4.532.5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110427"},{"key":"2023122109250663000_50.4.532.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes004"},{"key":"2023122109250663000_50.4.532.7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12969-016-0085-5","article-title":"Clinical outcome measures in juvenile idiopathic arthritis","volume":"14","author":"Consolaro","year":"2016","journal-title":"Pediatr Rheumatol Online J"},{"key":"2023122109250663000_50.4.532.8","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett","year":"1994","journal-title":"J Rheumatol"},{"key":"2023122109250663000_50.4.532.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094870"},{"key":"2023122109250663000_50.4.532.10","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/acr.22411","article-title":"Development and retrospective validation of the juvenile spondyloarthritis disease activity index","volume":"66","author":"Weiss","year":"2014","journal-title":"Arthritis Care Res"},{"key":"2023122109250663000_50.4.532.11","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/rheumatology\/key246","article-title":"Prospective validation of the Juvenile Spondyloarthritis Disease Activity Index in children with enthesitis-related arthritis","volume":"57","author":"Zanwar","year":"2018","journal-title":"Rheumatology"},{"key":"2023122109250663000_50.4.532.12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12969-017-0160-6","article-title":"The new Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry: design, rationale, and characteristics of patients enrolled in the first 12 months","volume":"15","author":"Beukelman","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"2023122109250663000_50.4.532.13","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181218"},{"key":"2023122109250663000_50.4.532.14","unstructured":"Cohen J. 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