{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:32:36Z","timestamp":1787844756045,"version":"build-2784847793"},"reference-count":50,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the association of early disease severity with grade 12 standards test performance in individuals with childhood-onset chronic rheumatic diseases (ChildCRDs), including juvenile arthritis and systemic autoimmune rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used linked provincial administrative data to identify patients with ChildCRDs born between 1979 and 1998 in Manitoba, Canada. Primary outcomes were Language and Arts Achievement Index (LAI) scores and Math Achievement Index (MAI) scores from grade 12 standards test results as well as enrollment data. The secondary outcome was enrollment in grade 12 by 17 years of age. Latent class trajectory analysis identified disease severity groups using physician visits following diagnosis. Multivariable linear regression tested the association of disease severity groups with LAI and MAI scores, and logistic regression tested the association of disease severity with age-appropriate enrollment, after adjusting for sociodemographic factors and psychiatric morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 541 patients, 70.1% of whom were female. A 3-class trajectory model provided the best fit; it classified 9.7% of patients as having severe disease, 54.5% as having moderate disease, and 35.8% as having mild disease. After covariate adjustment, severe disease was associated with poorer LAI and MAI scores but not with age-appropriate enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with ChildCRDs, those with severe disease performed more poorly on grade 12 standards tests, independent of sociodemographic and psychiatric risk factors. Clinicians should work with educators and policy makers to advocate for supports to improve educational outcomes of patients with ChildCRDs.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.220656","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T13:40:23Z","timestamp":1675258823000},"page":"1165-1172","source":"Crossref","is-referenced-by-count":2,"title":["Do Patterns of Early Disease Severity Predict Grade 12 Academic Achievement in Youths With Childhood-Onset Chronic Rheumatic Diseases?"],"prefix":"10.3899","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-0668","authenticated-orcid":false,"given":"Lily S.H.","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okechukwu","family":"Ekuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-5595","authenticated-orcid":false,"given":"Ruth A.","family":"Marrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-4404","authenticated-orcid":false,"given":"Marni","family":"Brownell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-5213","authenticated-orcid":false,"given":"Christine A.","family":"Peschken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-3268","authenticated-orcid":false,"given":"Carol A.","family":"Hitchon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-9172","authenticated-orcid":false,"given":"Kerstin","family":"Gerhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-3212","authenticated-orcid":false,"given":"Lisa M.","family":"Lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"2023090107351021000_50.9.1165.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3085-0"},{"key":"2023090107351021000_50.9.1165.2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130667"},{"key":"2023090107351021000_50.9.1165.3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00296-014-3136-6","article-title":"The prevalence of systemic autoimmune rheumatic diseases in Canadian pediatric populations: administrative database estimates","volume":"35","author":"Shiff","year":"2015","journal-title":"Rheumatol Int"},{"key":"2023090107351021000_50.9.1165.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.34499"},{"key":"2023090107351021000_50.9.1165.5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2431-13-2","article-title":"Impact of juvenile idiopathic arthritis on schooling","volume":"13","author":"Bouaddi","year":"2013","journal-title":"BMC Pediatr"},{"key":"2023090107351021000_50.9.1165.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.24100"},{"key":"2023090107351021000_50.9.1165.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.10444"},{"key":"2023090107351021000_50.9.1165.8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.12.1436"},{"key":"2023090107351021000_50.9.1165.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401219"},{"key":"2023090107351021000_50.9.1165.10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12969-017-0172-2","article-title":"Education and employment in patients with juvenile idiopathic arthritis - a standardized comparison to the German general population","volume":"15","author":"Schlichtiger","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"2023090107351021000_50.9.1165.11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/acr.22228","article-title":"Educational and vocational outcomes of adults with childhood- and adult-onset systemic lupus erythematosus: nine years of followup","volume":"66","author":"Lawson","year":"2014","journal-title":"Arthritis Care Res"},{"key":"2023090107351021000_50.9.1165.12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/acr.21637","article-title":"Quality of life in adults with juvenile-onset dermatomyositis: a case-control study","volume":"64","author":"Tollisen","year":"2012","journal-title":"Arthritis Care Res"},{"key":"2023090107351021000_50.9.1165.13","unstructured":"Brownell M , Chartier M , Au W , The educational outcomes of children in care in Manitoba. 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