{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:46:41Z","timestamp":1791524801038,"version":"4.3.4"},"reference-count":44,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate sleep quality in juvenile fibromyalgia syndrome (JFS) and its effect on the global burden of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with JFS who performed full-night polysomnography (PSG) were included in this cross-sectional study. JFS-related symptoms, neuropsychiatric features, and sleep quality were assessed using self-report measures. PSG sleep parameters, including N3 distribution index, were obtained from patients and age-matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 25 patients (20 females, median age 15.7 yrs). Nonrestorative sleep was reported by 22 of 25 (88%) patients. Patients with JFS showed significantly longer sleep period time (<jats:italic>P<\/jats:italic>= 0.004) and increased wake after sleep onset (<jats:italic>P<\/jats:italic>= 0.03) compared to healthy peers. The N3 distribution index was significantly lower in patients than in the control group (<jats:italic>P<\/jats:italic>= 0.02). Subjective poor sleep quality was related to Widespread Pain Index (WPI;<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u22120.65), Symptom Severity Scale (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u22120.64), depressive symptoms (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u22120.58), fatigue (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u22120.44), and symptom severity upon awakening (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u22120.65). The N3 distribution index was correlated to depressive symptoms (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>0.41) and irritability (r<jats:sub>s<\/jats:sub>0.40). On multiple regression analysis, WPI was predicted by subjective sleep quality (\u03b2 \u22120.32,<jats:italic>P<\/jats:italic>= 0.04), whereas depressive symptoms were predicted by subjective sleep measures (\u03b2 \u22120.32,<jats:italic>P<\/jats:italic>= 0.04) and PSG parameters (N3 min: \u03b2 \u22120.07,<jats:italic>P<\/jats:italic>= 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sleep complaints are a key hallmark of JFS and have significant effect on relevant clinical domains of the disease, such as pain and depression.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.220720","type":"journal-article","created":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T13:25:17Z","timestamp":1673789117000},"page":"827-834","source":"Crossref","is-referenced-by-count":10,"title":["Sleep and Sleep Complaints in Juvenile Fibromyalgia 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