{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:52:27Z","timestamp":1788609147785,"version":"build-2803163510"},"reference-count":14,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether patient and physician global assessment of gastrointestinal tract (GIT) disease in systemic sclerosis (SSc) are associated with a meaningful change in disease status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred forty-three participants from the Australian Scleroderma Cohort Study were recruited to this study. Using logistic regression analysis, we evaluated the relationship between patient-reported and physician-assessed GIT disease status and symptoms, measures of health-related quality of life (36-item Short Form Health Survey [SF-36]) and GIT disease severity, measured by the Scleroderma Clinical Trials Consortium UCLA Gastrointestinal Tract 2.0 (GIT 2.0) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient-reported worsening of GIT symptoms in the month preceding assessment was significantly associated with more severe GIT disease (odds ratio [OR] 6.14,<jats:italic>P<\/jats:italic>&lt; 0.01) and progressive worsening GIT disease severity as measured by the GIT 2.0 score (OR 45.98,<jats:italic>P<\/jats:italic>&lt; 0.01). The new onset of reflux was the only specific symptom associated with patient-reported GIT disease activity (OR 2.98,<jats:italic>P<\/jats:italic>= 0.04). Physician-assessed GIT disease activity was not significantly associated with higher GIT 2.0 scores or increasing severity of disease. Patient-reported and physician-assessed GIT activity was not associated with SF-36 scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the absence of objective measures of GIT disease activity in SSc, patient-reported symptoms of GIT disease could be used to indicate disease activity and should merit consideration for inclusion in a multisystem disease activity index.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.220832","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T13:20:23Z","timestamp":1668518423000},"page":"519-525","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Patient and Physician Assessments of Gastrointestinal Disease Activity in Systemic Sclerosis"],"prefix":"10.3899","volume":"50","author":[{"given":"Laura","family":"Ross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Proudman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nava","family":"Ferdowsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alannah","family":"Quinlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Morrisroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"2023122109250649000_50.4.519.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"2023122109250649000_50.4.519.2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/BOR.0000000000000645","article-title":"Gastrointestinal involvement in systemic sclerosis: an update","volume":"31","author":"McMahan","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"2023122109250649000_50.4.519.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.24730"},{"key":"2023122109250649000_50.4.519.4","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.237"},{"key":"2023122109250649000_50.4.519.5","first-page":"S42","article-title":"Assessment of disease severity and prognosis","volume":"21","author":"Medsger","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2023122109250649000_50.4.519.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401110"},{"key":"2023122109250649000_50.4.519.7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10067-019-04794-w","article-title":"The role of high-resolution manometry in the assessment of upper gastrointestinal involvement in systemic sclerosis: a systematic review","volume":"39","author":"Schutyser","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2023122109250649000_50.4.519.8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/BOR.0000000000000656","article-title":"Biomarkers in systemic sclerosis","volume":"31","author":"Skaug","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"2023122109250649000_50.4.519.9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/art.39501","article-title":"The American College of Rheumatology provisional composite response index for clinical trials in early diffuse cutaneous systemic sclerosis","volume":"68","author":"Khanna","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2023122109250649000_50.4.519.10","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/acr.24053","article-title":"Can patient-reported symptoms be used to measure disease activity in systemic sclerosis?","volume":"72","author":"Ross","year":"2020","journal-title":"Arthritis Care 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Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.220832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T17:25:30Z","timestamp":1703179530000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.220832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4,1]]},"published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.3899\/jrheum.220832"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.220832","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]}}}