{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:43:49Z","timestamp":1788536629985,"version":"build-2803163510"},"reference-count":24,"publisher":"Korean Association of Internal Medicine","issue":"6","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p>Background\/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC).Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015.Results: The most common locations of SMPESCC were mid- and lower thoracic segments (n = 208, 84.9%). The 1-, 2-, and 3-year overall survival rates were 53.8%, 30.8%, and 15.4%, respectively; the median survival time (MST) was 12.5 months. With definitive radiotherapy and surgery, respectively, the MST of stage I\/II patients were 34.2 and 26.7 months, of stage III patients were 8.3 and 13.2 months (&lt;i&gt;p&lt;\/i&gt; = 0.163), and of stage IV patients were and 8 and 12.6 months (&lt;i&gt;p&lt;\/i&gt; = 0.379). Clinical stage, family history of cancer, and Karnofsky performance status were independent prognostic factors for the whole cohort by Cox multivariate regression analysis (hazard ratio [HR] = 0.859, &lt;i&gt;p&lt;\/i&gt; &lt; 0.001; HR = 0.579, &lt;i&gt;p&lt;\/i&gt; = 0.032; and HR = 0.586, &lt;i&gt;p&lt;\/i&gt; = 0.013).Conclusions: Although the prognosis of SMPESCC is poor, stage I\/II patients can achieve long-term survival with aggressive treatment, especially those with a Karnofsky performance score 90 or higher and who have no family history of cancer. Definitive radiotherapy could achieve a similar survival rate to definitive surgery at different clinical stages.<\/jats:p>","DOI":"10.3904\/kjim.2017.280","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T08:41:00Z","timestamp":1525941660000},"page":"1356-1364","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell 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