{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:19:17Z","timestamp":1782872357156,"version":"3.54.5"},"reference-count":40,"publisher":"Korean Association of Internal Medicine","issue":"2","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1C1B5017457"],"award-info":[{"award-number":["2017R1C1B5017457"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Background\/Aims: Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups.Methods: We identified a total of 1,069 subjects who were tested for iron, ferritin, and total iron-binding capacity during their health check-ups, from January 2016 to May 2017. Of these, subjects who underwent endoscopy via rapid urease test and those aged 65 years or below were finally enrolled.Results: Overall, 281 subjects were enrolled, and 187 patients (66.5%) tested positive for H. pylori. The mean age was 36.1 years (range, 22 to 65), and 176 subjects (62.6%) were male. The mean levels of hemoglobin (14.1 \u00b1 1.7 g\/dL vs. 14.6 \u00b1 1.4 g\/dL, p = 0.019) and ferritin (121.7 \u00b1 106.9 ng\/mL vs. 151.8 \u00b1 107.8 ng\/mL, p = 0.027) in the H. pylori-positive group were significantly lower than those in the H. pylori-negative group. Iron deficiency (ferritin &lt; 30 ng\/mL) was more common in patients with H. pylori infection (p = 0.002). There was no significant difference in anemia (hemoglobin &lt; 13 g\/dL in men, &lt; 12 g\/dL in women) or IDA (anemia, ferritin &lt; 10 ng\/mL, and transferrin saturation &lt; 16%) with H. pylori. Logistic regression analysis demonstrated that female sex (odds ratio, 197.559; 95% confidence interval, 26.461 to 1,475.015) and H. pylori infection (odds ratio, 3.033; 95% confidence interval, 1.216 to 7.567) were factors associated with iron deficiency.Conclusions: H. pylori infection is associated with iron deficiency, suggesting a decline in iron stores among infected non-elderly adults.<\/jats:p>","DOI":"10.3904\/kjim.2020.433","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T04:41:51Z","timestamp":1639543311000},"page":"304-312","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program"],"prefix":"10.3904","volume":"37","author":[{"given":"Jun Yeop","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-4830","authenticated-orcid":true,"given":"Sung Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seun Ja","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo In","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae 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