{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:23:57Z","timestamp":1792567437855,"version":"4.5.0"},"reference-count":36,"publisher":"Korean Association of Internal Medicine","issue":"5","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>Background\/Aims: Despite the prominence of denosumab as the number one prescribed anti-osteoporosis drug in Korea, the effects of denosumab in male osteoporosis patients were not researched sufficiently. Moreover, concerns on rebound vertebral fractures associated with poor denosumab adherence exist.Methods: We retrospectively evaluated 147 Korean male osteoporosis patients treated with denosumab. After 12 months of treatment, 60 patients were lost during follow-up, and eight were excluded due to missing data. Out of the initial 147 patients, 79 were considered eligible for the analysis of the efficacy of denosumab. 54 patients were initially drug-na\u00efve, and 25 had previously received bisphosphonate therapy.Results: In 54 drug-na\u00efve patients, significant increases in bone mineral density (BMD) were observed in all measurement sites: 5.2% \u00b1 3.7% in the lumbar spine, 2.3% \u00b1 2.8% in the femoral neck, and 1.9% \u00b1 2.8% in the total hip (p &lt; 0.01, respectively). Trabecular bone score showed an increase of 0.5% \u00b1 5.8% in drug-na\u00efve patients. Likewise, in 25 patients with previous bisphosphonate treatment, increase in BMD were observed as well: 4.8% \u00b1 3.5% in the lumbar spine, 1.4% \u00b1 3.6% in the femoral neck, and 0.8% \u00b1 2.1% in the total hip (p &lt; 0.01, p = 0.06, p = 0.06, respectively). Significant declines of \u201355.1% \u00b1 31.8% in C-terminal telopeptide of type 1 collagen (CTX), and \u201362.9% \u00b1 21.3% in total procollagen 1 N-terminal propeptide (P1NP), in drug-na\u00efve patients; and \u201337.7% \u00b1 41.5%, in CTX and \u201355.4% \u00b1 30.1%, in P1NP in patients with previous bisphosphonate treatment were exhibited after 12 months of treatment. The adherence rates of the second and third dosing schedules were 79.9% and 56.8%, respectively.Conclusions: Our study indicates that denosumab is effective in increasing BMD in Korean osteoporosis males regardless of prior bisphosphonate treatment.<\/jats:p>","DOI":"10.3904\/kjim.2022.064","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T05:55:56Z","timestamp":1654235756000},"page":"1011-1020","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The efficacy of denosumab in Korean male patients with 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