{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:32:23Z","timestamp":1775611943713,"version":"3.50.1"},"reference-count":44,"publisher":"Korean Association of Internal Medicine","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p>Background\/Aims: Recent evidence has identified the significance of type 2 iodothyronine deiodinase (DIO2) in various diseases. However, the role of DIO2 polymorphism in metabolic parameters in patients with hypothyroidism is not fully understood.Methods: We assessed the polymorphism of the DIO2 gene and various clinical parameters in 118 patients who were diagnosed with hypothyroidism from the Ansan-Anseong cohort of the Korean Genome and Epidemiology Study. Furthermore, we systematically analyzed Genotype-Tissue Expression (GTEx) data.Results: A total of 118 participants with hypothyroidism were recruited; 32 (27.1%) were homozygous for the Thr allele, 86 (73.9%) were homozygous for the Ala allele or heterozygous. Patients with hypothyroidism with DIO2 polymorphism without hypertension at baseline had higher incidence of hypertension compared to patients without DIO2 polymorphism. Analysis of the GTEx database revealed that elevation of DIO2 expression is associated with enhancement of genes involved in blood vessel regulation and angiogenesis.Conclusions: Commonly inherited variation in the DIO2 gene is associated with high blood pressure and prevalence of hypertension in patients with hypothyroidism. Our results suggest that genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension.<\/jats:p>","DOI":"10.3904\/kjim.2022.292","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T04:26:20Z","timestamp":1673929580000},"page":"226-237","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study"],"prefix":"10.3904","volume":"38","author":[{"given":"Young Mi","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon Seok","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyon-Seung","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minho","family":"Shong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-3716","authenticated-orcid":true,"given":"Yea Eun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2270","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90095-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(92)90104-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.37.2.365"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.30.3.759"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1997.tb00167.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.3.e496"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8464"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.11.1.78"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0b013e328082e2ff"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0003319706293131"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.16.9250"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021592"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0455"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000256295.72185.fd"},{"key":"ref15","first-page":"313","volume-title":"Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase","author":"Mizuma","year":"2001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16345-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.088278"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.109454"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.155"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1172\/jci29812"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00371"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000469709"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1301"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7077-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv316"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1172\/jci123176"},{"key":"ref27","first-page":"145","volume-title":"Obesity phenotype and incident hypertension: a prospective community-based cohort study","author":"Lee","year":"2013"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.231"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-018-0098-0"},{"key":"ref30","first-page":"2199","volume-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association Task F","author":"Whelton","year":"2018"},{"key":"ref31","first-page":"1009","volume-title":"1999 World Health Organization-International Society of Hypertension guidelines for the management of hypertension. 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