{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:18Z","timestamp":1791229458335,"version":"4.1.0"},"reference-count":40,"publisher":"Korean Association of Internal Medicine","issue":"4","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"HK inno.N Corporation"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>Background\/Aims: Tegoprazan, a novel potassium-competitive acid blocker, has shown rapid action and gastric acid inhibition. In this study, we evaluated the efficacy of a tegoprazan-based, nonbismuth-containing quadruple (concomitant) therapy for the primary eradication of &lt;i&gt;Helicobacter pylori&lt;\/i&gt;.Methods: We conducted a prospective, single-arm, single-center, primitive study to verify the efficacy of a 10-day tegoprazan- based (50-mg dose) concomitant therapy, including amoxicillin (1,000-mg dose), clarithromycin (CLA; 500-mg dose), and metronidazole (MET; 500-mg dose) twice daily as a first-line treatment for &lt;i&gt;H. pylori&lt;\/i&gt; eradication.Results: We tested consecutive cultures for antibiotic susceptibility and minimum inhibitory concentrations. We enrolled 84 participants; 79 (94.0%) completed first-line therapy. The overall intention-to-treat and per-protocol eradication rates were 90.5% (95% confidence interval [CI], 82.1\u221295.8) and 96.2% (95% CI, 83.4\u201397.6), respectively. Of the 73 participants evaluated for antibiotic resistance, 19 (26.0%), 32 (42.5%), and 8 (11.0%) exhibited CLA, MET, and CLA and MET dual resistance, respectively. Of these, 39 participants (66.1%) exhibited successful eradication after the therapeutic regimen despite antibiotic resistance.Conclusions: The 10-day tegoprazan-based concomitant therapy may be an effective first-line treatment for eradicating &lt;i&gt;H. pylori&lt;\/i&gt;.<\/jats:p>","DOI":"10.3904\/kjim.2022.345","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T20:47:35Z","timestamp":1687898855000},"page":"493-503","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ten-day tegoprazan-based concomitant therapy as a first-line treatment for Helicobacter pylori eradication"],"prefix":"10.3904","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-9685","authenticated-orcid":true,"given":"Yong Hwan","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong 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