{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:56Z","timestamp":1791330056553,"version":"4.3.1"},"reference-count":30,"publisher":"Korean Association of Internal Medicine","issue":"3","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:p>Background\/Aims: Although anti-hepatitis C virus (HCV) assay is widely used to screen for HCV infection, it has a high false-positive (FP) rate in low-risk populations. We investigated the accuracy of anti-HCV signal-to-cutoff (S\/CO) ratio to distinguish true-positive (TP) from FP HCV infection.Methods: We retrospectively analyzed 77,571 patients with anti-HCV results. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S\/CO ratio in anti-HCV positive patients.Results: Overall, 1,126 patients tested anti-HCV positive; 34.7% of patients were FP based on HCV RNA and\/or recombinant immunoblot assay (RIBA) results. The age and sex-adjusted anti-HCV prevalence was 1.22%. We identified significant differences in serum aspartate transaminase and alanine transaminase levels, anti-HCV S\/CO ratio, and RIBA results between groups (viremia vs. non-viremia, TP vs. FP). Using ROC curves, the optimal cutoff values of anti-HCV S\/CO ratio for HCV viremia and TP were 8 and 5, respectively. The area under the ROC curve, sensitivity, specificity, positive and negative predictive values were 0.970 (95% CI, 0.959\u20130.982, p &lt; 0.001), 99.7%, 87.5%, 87.4%, and 99.7%, respectively, for predicting HCV viremia at an anti-HCV S\/CO ratio of 8 and 0.987 (95% CI, 0.980\u20130.994, p &lt; 0.001), 95.3%, 94.7%, 97.1%, and 91.4%, respectively, for TP HCV infection at an anti-HCV S\/CO ratio of 5. No patients with HCV viremia had an anti-HCV S\/CO ratio below 5.Conclusions: The anti-HCV S\/CO ratio is highly accurate for discriminating TP from FP HCV infection and should be considered when diagnosing HCV infections.<\/jats:p>","DOI":"10.3904\/kjim.2022.350","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:09:37Z","timestamp":1681171777000},"page":"362-371","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection"],"prefix":"10.3904","volume":"38","author":[{"given":"Jin Gu","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Kuk","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Han","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-1095","authenticated-orcid":true,"given":"Hyoung Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2270","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.014"},{"key":"ref2","first-page":"396","volume-title":"Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study","year":"2022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12108"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19272"},{"key":"ref5","volume-title":"","year":"2017"},{"key":"ref6","first-page":"135","volume-title":"Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology &amp; Hepatology Commission","author":"Cooke","year":"2019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713657"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31060"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00280.x"},{"key":"ref10","first-page":"1","volume-title":"Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. 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