{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:21:20Z","timestamp":1777386080262,"version":"3.51.4"},"reference-count":36,"publisher":"Korean Association of Internal Medicine","issue":"6","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Korean Association of Internal Medicine"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Background\/Aims: A previous history of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a risk factor for PEP, suggesting that there may be a genetic predisposition to PEP. However, nothing is known about this yet. The aim of this study was to identify genetic variations associated with PEP.Methods: A cohort of high-risk PEP patients was queried from December 2016 to January 2019. For each PEP case, two propensity score-matched controls were selected. Whole exome sequencing was performed using blood samples. Genetic variants reported to be related to pancreatitis were identified. To discover genetic variants that predispose to PEP, a logistic regression analysis with clinical adjustment was performed. Gene-wise analyses were also conducted.Results: Totals of 25 PEP patients and 50 matched controls were enrolled. Among the genetic variants reported to be associated with pancreatitis, only &lt;i&gt;CASR&lt;\/i&gt; rs1042636 was identified, and it showed no significant difference between the case and control groups. A total of 54,269 non-synonymous variants from 14,313 genes was identified. Logistic regression analysis of these variants showed that the &lt;i&gt;IRF2BP1&lt;\/i&gt; rs60158447 GC genotype was significantly associated with the occurrence of PEP (odds ratio 2.248, FDR q value = 0.005). Gene-wise analyses did not show any significant results.Conclusions: This study found that the &lt;i&gt;IRF2BP1&lt;\/i&gt; gene variant was significantly associated with PEP. This genetic variant is a highly targeted PEP risk factor candidate and can be used for screening high-risk PEP groups before ERCP through future validation. (ClinicalTrials.gov no. NCT02928718)<\/jats:p>","DOI":"10.3904\/kjim.2022.404","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:11:42Z","timestamp":1698027102000},"page":"854-864","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis"],"prefix":"10.3904","volume":"38","author":[{"given":"Young Hoon","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younggyun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Kee","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Won","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Kon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Hyun","family":"Paik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Han","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2174-9726","authenticated-orcid":true,"given":"Sang Hyub","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2270","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(04)00353-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.06.045"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i20.2495"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2021.410"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-19-26"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/473960"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1064783"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.49"},{"key":"ref9","first-page":"1414","volume-title":"A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis","author":"Elmunzer","year":"2012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(91)70740-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322498"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.186817"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.151688"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0b013e3282f5728c"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199809033391001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.045"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.44"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/mog.0b013e328349e2f8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000320560"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2730"},{"key":"ref21","volume-title":"FastQC: a quality control tool for high throughput sequence data [Internet]","author":"Andrews","year":"2010"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"ref23","volume-title":"Picard toolkit [Internet]","year":"2019"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"ref25","first-page":"80","volume-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; 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