{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:50:13Z","timestamp":1740153013197,"version":"3.37.3"},"reference-count":21,"publisher":"Korean Association of Internal Medicine","issue":"5","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["W1221325"],"award-info":[{"award-number":["W1221325"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p>Background\/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; have not been evaluated in the post-era of pneumococcal vaccination in Korea.Methods: We conducted a prospective, multi-center, cohort study from seven University-affiliated hospitals. The primary objective was the identification of serotype-specific prevalence of pneumococcal pneumonia in COPD patients hospitalized for CAP. For the purpose, we conducted serotype-specific urine antigen detection (SS-UAD) assays for &lt;i&gt;S. pneumoniae&lt;\/i&gt;. The secondary objectives were other clinical characteristics of pneumonia including vaccination status.Results: The total number of participants was 349. Most of them were male (95.1%) with old ages (75.55 \u00b1 8.59 y). The positive rate for &lt;i&gt;S. pneumoniae&lt;\/i&gt; was 9.2% with SS-UAD assay and the common serotypes were 22F, 6A, and 6B. In the sputum, &lt;i&gt;Pseudomonas aeruginosa&lt;\/i&gt; (5.0%) and &lt;i&gt;Haemophilus influenzae&lt;\/i&gt; (4.0%) were common pathogens. The vaccination rate was 78.8%, 53.0%, and 25.8% for influenza, pneumococcal polysaccharide vaccine 23 (PPV 23), and pneumococcal protein- conjugated vaccine 13 (PCV 13), respectively. Thirteen patients died during hospitalization (mortality rate; 3.7%). There was no difference in the respective rate of influenza vaccination (79.2% vs. 69.2%, &lt;i&gt;p&lt;\/i&gt; = 0.288) and PCV 13 vaccination (25.6% vs. 30.8%, &lt;i&gt;p&lt;\/i&gt; = 0.443) between survivors and the deceased.Conclusions: Serotypes 22F, 6A, and 6B, which are covered either by PPV 23 or by PCV 13, are still common pneumococcal serotypes in COPD pneumonia in the post-vaccination era in Korea.<\/jats:p>","DOI":"10.3904\/kjim.2023.152","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:04:32Z","timestamp":1692234272000},"page":"714-724","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study"],"prefix":"10.3904","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-4610","authenticated-orcid":true,"given":"Jae 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