{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:26:08Z","timestamp":1787239568753,"version":"build-2736575974"},"reference-count":34,"publisher":"Korean Association of Internal Medicine","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002636","name":"Inje University","doi-asserted-by":"publisher","award":["20220015"],"award-info":[{"award-number":["20220015"]}],"id":[{"id":"10.13039\/501100002636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Background\/Aims: The association between symptomatic knee osteoarthritis (OA) and higher cardiovascular disease (CVD) mortality is established; however, findings from studies that utilized regression analysis were limited, attributed to the strong association between OA and metabolic risk factors. This study aimed to evaluate the association between knee OA and mortality through propensity score matching.Methods: This was a cohort study including Korean National Health and Nutrition Examination Survey (2010\u20132013) participants aged \u2265 50 years. By linking the survey data to cause of death data (through 2019) from Statistics Korea, mortality and cause-specific mortality data were obtained. Radiographic knee OA (ROA) was defined as bilateral Kellgren\u2013Lawrence grade \u2265 2. Propensity score matching (1:1) was conducted between asymptomatic ROA, knee pain, and symptomatic ROA groups and normal groups, balancing the confounding factors. Time to death was analyzed using Cox proportional hazard modeling.Results: A higher CVD mortality was observed in the symptomatic ROA group, but not in others; the risk estimates were asymptomatic ROA (hazard ratio [HR] 1.12; 95% confidence interval [CI] 0.77\u20131.65), knee pain (HR 0.61; 95% CI 0.27\u20131.38), and symptomatic ROA (HR 1.39; 95% CI 0.89\u20132.17). No association was found between the all-cause\/cancer mortality and other groups.Conclusions: When propensity score matching controls metabolic risk factor imbalances, the association between symptomatic knee OA and higher CVD mortality was weaker compared to results of prior studies that used regression adjustment. The results may be more precise estimates of the total risk of knee OA for mortality in Koreans.<\/jats:p>","DOI":"10.3904\/kjim.2023.222","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T03:05:50Z","timestamp":1698807950000},"page":"923-933","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between knee osteoarthritis and mortality: a serial propensity score-matched cohort study"],"prefix":"10.3904","volume":"38","author":[{"given":"Minkyung","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Yeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Wook","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo-Ho","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyoung","family":"Her","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-9185","authenticated-orcid":true,"given":"Sunggun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2270","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.12795"},{"key":"ref2","first-page":"2271","volume-title":"Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991\u201394","author":"Dillon","year":"2006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031734"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1165"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy187"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208056"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.12.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.03.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01762-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.135"},{"key":"ref11","first-page":"169","volume-title":"Using Propensity scores to help design observational studies: application to the tobacco litigation","author":"Rubin","year":"2001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.36"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.163"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq159"},{"key":"ref15","first-page":"383","volume-title":"Negative controls: a tool for detecting confounding and bias in observational studies","author":"Lipsitch","year":"2010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000078924.61453.fb"},{"key":"ref17","first-page":"337","volume-title":"EQ-5D: a measure of health status from the EuroQol Group","author":"Rabin","year":"2001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1037\/e565682010-001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-s002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/art.41027"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24808"},{"key":"ref24","first-page":"45","volume-title":"Long-term mortality rates and associated risk factors following primary and revision knee arthroplasty: 107,121 patients from the Scottish Arthroplasty Project","author":"Yapp","year":"2022"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.09.015"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071652"},{"key":"ref27","first-page":"322","volume-title":"Diagnosis and management of the metabolic syndrome. 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