{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:15:28Z","timestamp":1784542528806,"version":"3.55.0"},"reference-count":36,"publisher":"Korean Association of Internal Medicine","issue":"3","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000703"],"award-info":[{"award-number":["82000703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Affiliated Hospital of Xuzhou Medical University","award":["XYFY202332"],"award-info":[{"award-number":["XYFY202332"]}]},{"DOI":"10.13039\/501100018636","name":"Xuzhou science and technology project","doi-asserted-by":"crossref","award":["KC23212"],"award-info":[{"award-number":["KC23212"]}],"id":[{"id":"10.13039\/501100018636","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p>Background\/Aims: Roxadustat, an oral medication for treating renal anemia, is a hypoxia-inducible factor prolyl hydroxylase inhibitor used for regulating iron metabolism and promoting erythropoiesis. To investigate the efficacy and safety of roxadustat in patients undergoing peritoneal dialysis (PD) with erythropoietin hyporesponsiveness.Methods: Single-center, retrospective study, 81 PD patients (with erythropoietin hyporesponsiveness) were divided into the roxadustat group (n = 61) and erythropoiesis-stimulating agents (ESAs) group (n = 20). Hemoglobin (Hb), total cholesterol, intact parathyroid hormone (iPTH), brain natriuretic peptide (BNP), related indicators of cardiac function and high-sensitivity C-reactive protein (hs-CRP) were collected. Additionally, adverse events were also recorded. The follow-up period was 16 weeks.Results: The two groups exhibited similar baseline demographic and clinical characteristics. At baseline, the roxadustat group had a mean Hb level of 89.8 \u00b1 18.9 g\/L, while the ESAs group had a mean Hb level of 95.2 \u00b1 16.0 g\/L. By week 16, the Hb levels had increased to 118 \u00b1 19.8 g\/L (p &lt; 0.05) in the roxadustat group and 101 \u00b1 19.3 g\/L (p &gt; 0.05) in the ESAs group. The efficacy of roxadustat in improving anemia was not influenced by baseline levels of hs-CRP and iPTH. Cholesterol was decreased in the roxadustat group without statin use. An increase in left ventricular ejection fraction and stabilization of BNP were observed in the roxadustat group.Conclusions: For PD patients with erythropoietin hyporesponsiveness, roxadustat can significantly improve renal anemia. The efficacy of roxadustat in improving renal anemia was not affected by baseline levels of hs-CRP0 and iPTH.<\/jats:p>","DOI":"10.3904\/kjim.2023.520","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:36:40Z","timestamp":1713832600000},"page":"488-500","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A retrospective study on the efficacy of Roxadustat in peritoneal dialysis patients with erythropoietin 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