{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:13:33Z","timestamp":1793038413769,"version":"4.5.0"},"reference-count":36,"publisher":"Korean Association of Internal Medicine","issue":"6","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Korean Association of Internal Medicine"},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IP0024"],"award-info":[{"award-number":["2023IP0024"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:p>Background\/Aims: Despite the possible role of systemic low-grade inflammation on frailty, the majority of previous studies have focused solely on the phenotypic frailty with limited participant numbers, thereby weakening the evidence supporting the notion that circulating C-reactive protein (CRP) could be a potential frailty biomarker.Methods: This study is a nationally representative, population-based, cross-sectional analysis from the Korea National Health and Nutrition Examination Survey, involving 5,359 participants aged 65 and older. We generated a deficit accumulation frailty index (FI) based on 38 items, encompassing physical, cognitive, psychological, and social status. Frailty was classified as non-frail (FI \u2264 0.15), pre-frail (0.15 &lt; FI \u2264 0.25), or frail (FI &gt; 0.25). Serum high-sensitivity CRP (hsCRP) levels were measured by immunoturbidometric method.Results: After adjusting for confounders including age, sex, income, education, smoking, hypertension, diabetes, dyslipidemia, stroke, cardiovascular diseases, and body mass index, serum hsCRP levels were 29.4% higher in frail participants compared to their non-frail counterparts (&lt;i&gt;p&lt;\/i&gt; = 0.001). Additionally, circulating hsCRP concentrations positively correlated with the FI (&lt;i&gt;p&lt;\/i&gt; = 0.003), and the odds ratio for frailty per standard deviation increase in serum hsCRP was 1.18 (&lt;i&gt;p&lt;\/i&gt; = 0.001). Moreover, older adults in the highest hsCRP quartile exhibited a significant higher FI with a 1.59-fold increased odds ratio for frailty than those in the lowest quartile (&lt;i&gt;p&lt;\/i&gt; = 0.002 and 0.001, respectively).Conclusions: These findings validate the impact of age-related systemic low-grade inflammation on frailty and support the utility of serum hsCRP as a potential biomarker for detecting frailty in older adults.<\/jats:p>","DOI":"10.3904\/kjim.2024.050","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T04:08:31Z","timestamp":1721707711000},"page":"1011-1020","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based 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