{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:56:49Z","timestamp":1781355409857,"version":"3.54.1"},"reference-count":32,"publisher":"Korean Association of Internal Medicine","issue":"3","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2B5B02001602"],"award-info":[{"award-number":["2022R1A2B5B02001602"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022M3A9E4082647"],"award-info":[{"award-number":["2022M3A9E4082647"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003562","name":"Ministry of Environment","doi-asserted-by":"publisher","award":["2024ER090500"],"award-info":[{"award-number":["2024ER090500"]}],"id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003562","name":"Ministry of Environment","doi-asserted-by":"publisher","award":["RS-2022-KE002197"],"award-info":[{"award-number":["RS-2022-KE002197"]}],"id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>Background\/Aims: Patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) typically have a poor prognosis; however, no effective treatment is available. In recent years, several retrospective studies have suggested the clinical benefits of direct hemoperfusion with a polymyxin B\u2013immobilized fiber column (PMX-DHP) in patients with AE-IPF. Herein, we aimed to investigate the efficacy and safety of PMX-DHP treatment in patients with AE-IPF.Methods: Patients diagnosed with AE-IPF (n = 10) with a partial pressure of oxygen to fraction of inspiratory oxygen ratio (P\/F ratio) &gt; 100 were prospectively enrolled at a single center. PMX-DHP was performed twice for 6 hours (at 24-h intervals) at a flow rate of 80\u2013100 mL\/min, and steroid pulse therapy was concurrently administered (500 mg of methylprednisolone for 3 d).Results: The mean patient age was 67 years, and 80.0% were male. During the follow-up (median, 42.5 d; interquartile range, 16.0\u2013174.0 d), seven (70.0%) patients died (including two who underwent transplantation); the in-hospital mortality rate was 70%, while the 30- and 90-day mortality rates were 50.0% and 70.0%, respectively. After 48 hours of PMX-DHP treatment, the P\/F ratio improved (mean, 160.0 vs. 229.0; p = 0.054) and C-reactive protein level decreased (mean, 8.3 mg\/dL vs. 3.5 mg\/dL; p = 0.012). During hospitalization, no PMX-DHP\u2013associated adverse events were observed.Conclusions: Our results suggest that PMX-DHP treatment may be useful at improving oxygenation and reducing inflammation in patients with AE-IPF with acceptable safety profiles, however without affecting their prognosis.<\/jats:p>","DOI":"10.3904\/kjim.2024.244","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:25:51Z","timestamp":1745997951000},"page":"458-467","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymyxin B-hemoperfusion in patients with acute exacerbation of idiopathic pulmonary fibrosis: a single-center prospective pilot study"],"prefix":"10.3904","volume":"40","author":[{"given":"Min Jee","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoul","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-3522","authenticated-orcid":true,"given":"Jin Woo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2270","reference":[{"key":"ref1","first-page":"e44","volume-title":"Diagnosis of idiopathic pulmonary fibrosis. an Official ATS\/ERS\/JRS\/ALAT clinical practice guideline","author":"Raghu","year":"2018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159709"},{"key":"ref3","first-page":"265","volume-title":"Acute exacerbation of idiopathic pulmonary fibrosis. an International Working Group report","author":"Collard","year":"2016"},{"key":"ref4","first-page":"788","volume-title":"An official ATS\/ERS\/JRS\/ALAT 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