{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:16:43Z","timestamp":1776226603235,"version":"3.50.1"},"reference-count":38,"publisher":"Korean Association of Internal Medicine","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>Background\/Aims: The impact of body mass index (BMI) on the clinical outcomes of intestinal Beh\u00e7et\u2019s disease (BD) remains unclear. This study assessed the association between BMI and disease progression.Methods: A retrospective analysis of 760 patients with intestinal BD was conducted. Patients were classified by BMI as underweight (&lt; 18.5 kg\/m2), normal (18.5\u201322.9), overweight (23.0\u201324.9), or obese (\u2265 25.0). The association between BMI and clinical outcomes\u2014biologics, surgery, hospitalization, and emergency visits\u2014was examined.Results: Among 760 patients, 130 (17.1%) were underweight, 384 (50.5%) normal, 152 (20.0%) overweight, and 94 (12.4%) obese. Higher BMI linked to lower cumulative rates of biologics use (p trend = 0.002), surgery (p trend = 0.004), hospitalization (p trend = 0.004), and emergency visits (p trend = 0.008). Compared with the underweight group, the normal (HR 0.667, 95% CI 0.483\u20130.922, p = 0.014), overweight (HR 0.589, 95% CI 0.394\u20130.879, p = 0.010), and obese groups (HR 0.515, 95% CI 0.321\u20130.828, p = 0.006) had lower hospitalization risks. The overweight (HR 0.490, 95% CI 0.241\u20130.996, p = 0.049) and obese (HR 0.312, 95% CI 0.116\u20130.840, p = 0.021) groups were negatively associated with future biologics use. The normal (HR 0.705, 95% CI 0.480\u20131.036, p = 0.075) and obese (HR 0.510, 95% CI 0.272\u20130.953, p = 0.035) groups were negatively associated with future surgery in multivariable analysis.Conclusions: Lower BMI was linked to poorer clinical outcomes in intestinal BD, emphasizing the need to optimize nutritional status.<\/jats:p>","DOI":"10.3904\/kjim.2024.349","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T01:50:48Z","timestamp":1751334648000},"page":"606-615","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of body mass index on clinical outcomes in intestinal Beh\u00e7et\u2019s 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