{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:17:20Z","timestamp":1792790240044,"version":"4.5.0"},"reference-count":72,"publisher":"Korean Association of Internal Medicine","issue":"6","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["RS-2024-00507932"],"award-info":[{"award-number":["RS-2024-00507932"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Society of Cardio-cerebrovascular Disease Prevention Research Award"},{"DOI":"10.13039\/501100015825","name":"Korea University Anam Hospital","doi-asserted-by":"crossref","award":["O2207691"],"award-info":[{"award-number":["O2207691"]}],"id":[{"id":"10.13039\/501100015825","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>Patients with chronic kidney disease (CKD) have a significantly increased risk of developing cardiovascular disease (CVD), making dyslipidemia management a critical component of cardiovascular risk reduction in this population. However, as the estimated glomerular filtration rate declines, distinct pathophysiological mechanisms\u2014unlike those observed in the general population\u2014contribute to the development and progression of CVD. Consequently, dyslipidemia management in patients with CKD requires a tailored approach that considers altered lipid profiles, comorbid conditions, and potential safety concerns associated with pharmacological therapy. This review aimed to summarize key clinical trials evaluating lipid-lowering strategies in CKD and compare current international and regional clinical practice guidelines. We assessed cardiovascular outcomes associated with various lipid-lowering agents, including statins, ezetimibe, proprotein convertase subtilisin\/kexin type 9 inhibitors, fibrates, and omega-3 fatty acids. In addition, we discuss optimal therapeutic strategies across distinct patient subgroups, including those not treated with dialysis or kidney transplantation, those on dialysis, and kidney transplant recipients.<\/jats:p>","DOI":"10.3904\/kjim.2025.099","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:13:10Z","timestamp":1761898390000},"page":"876-889","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations"],"prefix":"10.3904","volume":"40","author":[{"given":"Ji Yoon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk 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