{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:15:47Z","timestamp":1789460147891,"version":"build-2803163510"},"reference-count":27,"publisher":"Korean Association of Internal Medicine","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["kjim.org"],"crossmark-restriction":true},"short-container-title":["Korean J Intern Med"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>Background\/Aims: Parathyroid hormone\u2013related protein (PTHrP) is a major mediator of hypercalcemia in patients with malignancy; however, understanding of PTHrP-mediated hypercalcemia remains limited because available evidence has largely been derived from small case series.Methods: We retrospectively analyzed electronic medical records from eight hospitals affiliated with The Catholic University of Korea. Adult patients (&gt; 20 years) with confirmed malignancy and albumin-corrected hypercalcemia (\u2265 10.5 mg\/dL) between 2013 and 2022 were identified and classified as having PTHrP-mediated hypercalcemia (PTHrP &gt; 1.1 pmol\/L) or hypercalcemia due to other causes (PTHrP \u2264 1.1 pmol\/L).Results: Among the 289 patients reported to have PTHrP-mediated hypercalcemia, median age was 66 years (interquartile range [IQR], 59\u201375) and median plasma PTHrP level was 6.1 pmol\/L (IQR, 3.5\u201311.5). Solid tumors accounted for 86% of cases, while hematologic malignancies accounted for the other 14%. The most common cancer types were lung cancer (30%, n = 87), head and neck cancer (11%, n = 31), and multiple myeloma (8%, n = 24). Median survival after the onset of hypercalcemia was 46 days (95% confidence interval [CI], 36\u201361) in patients with PTHrP-mediated hypercalcemia. Compared with the 169 patients with hypercalcemia due to other causes, PTHrP-mediated hypercalcemia was associated with a higher risk of mortality after adjustment for age, corrected calcium level, and cancer type (adjusted hazard ratio, 4.0; 95% CI, 2.9\u20135.4).Conclusions: PTHrP-mediated hypercalcemia occurs across a broad spectrum of malignancies and is associated with worse clinical outcomes.<\/jats:p>","DOI":"10.3904\/kjim.2026.092","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:15:56Z","timestamp":1788747356000},"page":"907-915","update-policy":"https:\/\/doi.org\/10.3904\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parathyroid hormone\u2013related protein\u2013mediated hypercalcemia of malignancy: insights from a multicenter clinical data warehouse"],"prefix":"10.3904","volume":"41","author":[{"given":"Jinyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghoon","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaiho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanhoon","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Won","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seung","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihnsuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Daejeon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jun","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk-Sang","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Ho","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-1077","authenticated-orcid":true,"given":"Ki-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2270","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026597816193","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/jop.2016.011155","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/nejm194111132252007","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.14.5048","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199004193221603","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.3616618","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp042806","type":"journal-article"},{"key":"ref8","first-page":"510","type":"journal-article","volume-title":"Physiological roles of parathyroid hormone-related protein","author":"Lai","year":"2019"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2142","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp2113128","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1309\/lm23td4iutajbjmg","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2007090981","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.18.12931","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(02)00685-3","type":"journal-article"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220818","type":"journal-article"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9629(15)41844-0","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1430333","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/med.0b013e32834b4401","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4250","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2017.24.4.249","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.040","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-852459","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v100.6.2195.h81802002195_2195_2202","type":"journal-article"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.6096","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2022","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-7-499","type":"journal-article"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020314","type":"journal-article"}],"container-title":["The Korean Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/kjim.org\/upload\/kjim-2026-092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/kjim.org\/journal\/view.php?doi=10.3904\/kjim.2026.092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/kjim.org\/upload\/kjim-2026-092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:59:28Z","timestamp":1789459168000},"score":1,"resource":{"primary":{"URL":"http:\/\/kjim.org\/journal\/view.php?doi=10.3904\/kjim.2026.092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.3904\/kjim.2026.092","relation":{},"ISSN":["1226-3303","2005-6648"],"issn-type":[{"value":"1226-3303","type":"print"},{"value":"2005-6648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}