{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:13:11Z","timestamp":1780477991987,"version":"3.54.1"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Biol"],"abstract":"<jats:p>Transformed follicular lymphoma (tFL) originates from histological transformation of follicular lymphoma (FL), which is\nthe most common indolent non-Hodgkin lymphoma. High-resolution genomic copy-number analysis previously identified frequent\namplification of the 2p15-p16.1 locus in FL and tFL cases. The genes (i.e. BCL11A, PAPOLG, PUS10, and USP34) in this amplified\nlocus have not been systematically investigated to date in terms of their role in FL pathogenesis or transformation to tFL. Here we\ninvestigated the relationship between amplification and expression of genes in 2p15-p16.1 as well as their expression after histological\ntransformation. NCBI GEO SNP array and gene expression profile (GEP) data of tFL cases were analyzed to evaluate the relationship\nbetween amplification and mRNA expression. Moreover, transcript levels of these four genes in FL cases were compared with those\nof patient-matched tFL cases and normal B-cells. Amplification of the 2p15-p16.1 locus is associated with increased transcription of\nBCL11A and PAPOLG in tFL cases, of which the latter showed increased expression after histological transformation. Compared with\nthe level in normal B-cells, PAPOLG was significantly overexpressed in FL cases, but expression levels of the other three genes did not\nshow any significant difference. Altogether these results suggest that PAPOLG may be the most critical gene in terms of transformation\nto tFL.<\/jats:p>","DOI":"10.3906\/biy-1810-2","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T10:51:07Z","timestamp":1555411867000},"page":"124-132","source":"Crossref","is-referenced-by-count":6,"title":["Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals PAPOLG as a potential proto-oncogene in follicular and transformed follicular lymphoma"],"prefix":"10.55730","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-1242","authenticated-orcid":false,"given":"Deniz","family":"KUR\u015eUN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5540-9012","authenticated-orcid":false,"given":"Can","family":"K\u00dc\u00c7\u00dcK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2019,4,5]]},"container-title":["TURKISH JOURNAL OF BIOLOGY"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:20:37Z","timestamp":1655709637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/biology\/vol43\/iss2\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3906\/biy-1810-2","archive":["Portico"],"relation":{},"ISSN":["1303-6092"],"issn-type":[{"value":"1303-6092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,5]]}}}