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(2017). Recent trends in ZikV research: A step away from cure. Biomedicine & Pharmacotherapy 91: 1152-1159. doi: 10.1016\/j.biopha.2017.05.045","DOI":"10.1016\/j.biopha.2017.05.045"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Arabi YM, Alothman A, Balkhy HH, Al-Dawood A, AlJohani S et al. (2018). Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-\u03b21b (MIRACLE trial): study protocol for a randomized controlled trial. Trials 19. Article no: 81. doi: 10.1186\/s13063-017-2427-0","DOI":"10.1186\/s13063-017-2427-0"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A et al. (2014). Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. 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