{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:48:25Z","timestamp":1747223305907,"version":"3.40.5"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Med Sci"],"abstract":"<jats:p>Background and Aims: Tinnitus, which affects 15% of general populations and in 1-6%, the quality-of-life is seriously affected by a chronic condition. Chemical, oxidative, and emotional stressors are important in terms of the clinical course of tinnitus. Apelin mediates oxidative stress. We measured apelin levels in patients with tinnitus affecting both ears, but without hearing loss. \nMaterial and Methods: We enrolled patients diagnosed with bilateral idiopathic tinnitus. Tinnitus severity was determined using the Tinnitus Handicap Inventory. We recorded the levels of plasma apelin-13 and biochemical parameters. \nResults: The mean apelin level of the control group was higher than that of the patient group (p = 0.002). A significant negative correlation was evident between the apelin level and the THI (r = 0.460, p = 0.003). The TG level was significantly higher in the patient than the control group (p &lt; 0.001). \nConclusions: As tinnitus severity increased, the apelin level fell. Thus, apelin may play a role in the pathophysiology of idiopathic tinnitus, and may be prescribed during follow-up to reduce oxidative stress in the future. Further clinical studies on the effects of the apelin\/APJ system and the effects of antioxidants in patients with inflammatory diseases, are required. \nKey words: apelin, oxidative stress, tinnitus<\/jats:p>","DOI":"10.3906\/sag-1812-11","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T13:50:39Z","timestamp":1552571439000},"source":"Crossref","is-referenced-by-count":1,"title":["Can Apelin play a role in the etiology of tinnitus?"],"prefix":"10.55730","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-9173","authenticated-orcid":false,"given":"Nuray","family":"ENSAR\u0130","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-4136","authenticated-orcid":false,"given":"\u00d6zer Erdem","family":"G\u00dcR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-0585","authenticated-orcid":false,"given":"Nilg\u00fcn","family":"G\u00dcR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-7599","authenticated-orcid":false,"given":"\u00d6mer Tar\u0131k","family":"SEL\u00c7UK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-2294","authenticated-orcid":false,"given":"Levent","family":"RENDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-0229","authenticated-orcid":false,"given":"Mustafa Deniz","family":"YILMAZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-186X","authenticated-orcid":false,"given":"Mehmet T\u00fcrker","family":"\u00d6ZT\u00dcRK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-5618","authenticated-orcid":false,"given":"Ye\u015fim","family":"\u00c7EK\u0130N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34691","published-online":{"date-parts":[[2019,3,5]]},"container-title":["TURKISH JOURNAL OF MEDICAL SCIENCES"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:21:13Z","timestamp":1655709673000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol49\/iss3\/10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3906\/sag-1812-11","archive":["Portico"],"relation":{},"ISSN":["1303-6165"],"issn-type":[{"type":"electronic","value":"1303-6165"}],"subject":[],"published":{"date-parts":[[2019,3,5]]}}}