{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T06:03:16Z","timestamp":1750485796828,"version":"3.37.3"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Med Sci"],"abstract":"<jats:p>Background\/aim: The aim of the study was to evaluate the protective effect of Botulinum A toxin injection against ischemia-reperfusion injury.Materials and methods: Thirty-two Sprague-Dawley rats were divided into: control, ischemia-reperfusion, ischemic preconditioning, and botulinum groups. In all groups the musculocutaneous pedicle flap was occluded for 4 h, and then reperfused to induce ischemia-reperfusion injury. Serum and tissue myeloperoxidase (MPO) and nitric oxide (NO) levels were measured at 24 h and at 10 days.Results: Tissue MPO levels did not differ significantly between the ischemic preconditioning and botulinum groups at 24 h but was significantly lower in the botulinum group at 10 days. Tissue NO levels were significantly higher in the ischemic preconditioning group compared to the botulinum group at 24 h and at 10 days. Serum MPO showed no significant difference between these two groups at 24 h but was significantly lower in the ischemic preconditioning group compared to the botulinum group at 10 days. Serum NO levels were not significantly different at 24 h but significantly higher in the botulinum group at 10 days.Conclusion: Findings  show  that  botulinum  has  a  protective  effect  against  the  ischemia-reperfusion  injury  via  increased  NO  and  decreased MPO levels in tissue. Based on tissue NO levels, ischemic preconditioning was significantly higher than botulinum.<\/jats:p>","DOI":"10.3906\/sag-1904-95","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T05:50:04Z","timestamp":1595915404000},"page":"1523-1534","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of ischemic preconditioning and BotulinumA Toxin injection for the prevention of ischemia-reperfusion injury in musculocutaneous flaps"],"prefix":"10.55730","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-4672","authenticated-orcid":false,"given":"Handan","family":"DEREBA\u015eINLIO\u011eLU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-6939","authenticated-orcid":false,"given":"An\u0131l","family":"DEM\u0130R\u00d6Z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-8482","authenticated-orcid":false,"given":"Ya\u011fmur","family":"AYDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5605-2980","authenticated-orcid":false,"given":"Hakan","family":"EKMEK\u00c7\u0130","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-9915","authenticated-orcid":false,"given":"\u00d6zlem","family":"BALCI EKMEK\u00c7\u0130","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-8816","authenticated-orcid":false,"given":"\u00d6vg\u00fc","family":"AYDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-1470","authenticated-orcid":false,"given":"Levent","family":"CANKORKMAZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34691","published-online":{"date-parts":[[2020,10,22]]},"container-title":["TURKISH JOURNAL OF MEDICAL SCIENCES"],"original-title":[],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:23:29Z","timestamp":1655709809000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol50\/iss6\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,10,22]]}},"URL":"https:\/\/doi.org\/10.3906\/sag-1904-95","relation":{},"ISSN":["1303-6165"],"issn-type":[{"type":"electronic","value":"1303-6165"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}