{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:53:27Z","timestamp":1790013207476,"version":"4.0.1"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Med Sci"],"abstract":"<jats:p>Background\/aim: Ischemia is insufficient blood flow to provide adequate oxygenation. In the present study, we aimed to show whether acute hypoxia has a critical oxygen value that may lead to the deterioration of cochlear function.Materials and methods: Under general anesthesia, prehypoxic signal-to-noise ratios were determined by distortion product otoacoustic emissions (DPOAE). The oxygen saturation (SaO2) values   of rats were monitored with an oxygen saturation probe. Rats were injected with an extra dose of anesthetic agent, and SaO2 was reduced. DPOAE values in SaO2 100\u201390, 90\u201380, 80\u201370, and 70\u201360 posthypoxic values  were measured and compared statistically with prehypoxic values.Results: At 3000 and 4000 Hz, SaO2 70\u201360 values measured after the hypoxia were observed to be statistically significantly lower than the values measured before the hypoxia. At 6000 and 8000 Hz, SaO2 80\u201370 and 70\u201360 values measured after the hypoxia were observed to  be  statistically  significantly  lower  than  the  values  measured  before  the  hypoxia.  At  10,000  Hz,  all  of  the  values  measured  after  the  hypoxia were observed to be statistically significantly lower than the values obtained before the hypoxia.Conclusion: Many  studies  have  been  conducted  on  the  effects  of  hypoxia  on  the  inner  ear.  It  remains  unclear  how  fluctuations  in  DPOAE levels affect hearing in clinical trials when the SaO2 starts to decrease. Although hypoxia has been implicated in the etiology of sudden hearing loss and tinnitus, the effects of acute hypoxia on the cochlea are still uncertain. Further studies are needed on this subject.<\/jats:p>","DOI":"10.3906\/sag-1911-166","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T02:39:36Z","timestamp":1597113576000},"page":"1580-1584","source":"Crossref","is-referenced-by-count":5,"title":["Effects of acute hypoxia on auditory pathway of Wistar albino rats"],"prefix":"10.55730","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-7693","authenticated-orcid":false,"given":"Nevreste Didem","family":"SONBAY YILMAZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7375-1070","authenticated-orcid":false,"given":"Cem","family":"SAKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5058-1400","authenticated-orcid":false,"given":"Sibel","family":"AL\u0130CURA TOKG\u00d6Z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-102X","authenticated-orcid":false,"given":"Murat","family":"\u00c7ALI\u015eKAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-551X","authenticated-orcid":false,"given":"Erkan","family":"VURALKAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7819-9094","authenticated-orcid":false,"given":"\u00d6mer","family":"BE\u015eALTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2020,10,22]]},"container-title":["TURKISH JOURNAL OF MEDICAL SCIENCES"],"original-title":[],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T03:23:28Z","timestamp":1655695408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol50\/iss6\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,10,22]]}},"URL":"https:\/\/doi.org\/10.3906\/sag-1911-166","relation":{},"ISSN":["1303-6165"],"issn-type":[{"value":"1303-6165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}