{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:07:23Z","timestamp":1779206843022,"version":"3.51.4"},"reference-count":0,"publisher":"IMR Press","issue":"S1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Cardiovascular disease mortality rates have begun to rise in the United States. Based on the large body of supportive evidence, we propose a proof-of-concept, first-in-human trial to cure atherosclerosis: CURing Early ATHEROsclerosis (CURE ATHERO). This trial is based on a model of intensive induction therapy for extensive, if not complete, plaque regression, followed by intermittent maintenance therapy. An extensive body of evidence has demonstrated the causal role of apolipoprotein B lipoproteins in atherosclerosis progression and data suggest intensive low-density lipoprotein cholesterol (LDL-C) lowering may have a substantial impact on earlier stages of atherosclerosis. Compared with lifetime treatment to prevent atherosclerosis progression, this induction\u2013intermittent treatment model will minimize costs and maximize adherence and safety.<\/jats:p>","DOI":"10.3909\/ricm19s1s0003","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:59:00Z","timestamp":1648429140000},"source":"Crossref","is-referenced-by-count":18,"title":["Can We Cure Atherosclerosis?"],"prefix":"10.31083","volume":"19","author":[{"given":"Jennifer G.","family":"Robinson","sequence":"first","affiliation":[{"name":"Departments of Epidemiology & Medicine, University of Iowa College of Public Health and Carver College of Medicine, Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Davidson","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Chicago Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2018,1,20]]},"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/19\/S1\/10.3909\/ricm19S1S0003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:53:04Z","timestamp":1732726384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/19\/S1\/10.3909\/ricm19S1S0003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,20]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2018]]}},"alternative-id":["1550738116043-871060853"],"URL":"https:\/\/doi.org\/10.3909\/ricm19s1s0003","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,20]]},"article-number":"20"}}