{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:43:42Z","timestamp":1780353822487,"version":"3.54.1"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:p>Strains of <jats:italic>Saccharomyces boulardii<\/jats:italic>, a probiotic yeast, have been found to be effective in the treatment of diarrhoea,\ninflammatory bowel disease, irritable bowel syndrome and other conditions. In the present study, Unique 28, a strain\nof <jats:italic>S. boulardii<\/jats:italic> isolated and characterised in our laboratory, was evaluated for its safety assessment. Acute and subacute\ntoxicity tests were performed in rats. The dose of Unique 28 (5\u00d710<jats:sup>9<\/jats:sup> cfu\/g) fed orally was, up to 6,500 mg per\nkg of b.w. (body weight) for acute toxicity and up to 1,300 mg per kg of b.w. for sub-acute toxicity studies. This dose\nwas well tolerated and there was no morbidity or any kind of toxic clinical symptoms displayed either in male or\nfemale rats. Moreover, the results of sub-acute toxicity studies using Unique 28 administered for 14 weeks indicated\nthat there were no clear unwanted treatment related effects. Overall results of this toxicology assessment indicate\nthat Unique 28 is safe for human consumption.<\/jats:p>","DOI":"10.3920\/bm2011.0013","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T01:06:37Z","timestamp":1318295197000},"page":"221-227","source":"Crossref","is-referenced-by-count":8,"title":["Safety assessment studies of probiotic Saccharomyces boulardii strain Unique 28 in Sprague-Dawley rats"],"prefix":"10.1163","volume":"2","author":[{"given":"M. Ratna","family":"Sudha","sequence":"first","affiliation":[{"name":"Centre for Research & Development, Unique Biotech Limited, SP Biotech Park, Phase-II, Plot-2, Shameerpet, Hyderabad 500078, AP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.5340-5343.2003"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03442.x"},{"key":"atypb4","first-page":"1357","volume":"17","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(98)80008-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i8.1832"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.430s"},{"key":"atypb10","first-page":"77","volume":"12","journal-title":"Medecine et Chirurgie Digestives"},{"key":"atypb11","first-page":"2613","volume":"36","journal-title":"inval.). Journal of Clinical Microbiology"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3109\/08910609309141323"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.aut-02-16"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00209.x"},{"key":"atypb18","first-page":"220","volume":"51","journal-title":"Turkish Journal of Paediatrics"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91613-2"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199903000-00003"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/2\/3\/article-p221_221.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/2\/3\/article-p221_221.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/2\/3\/article-p221_221.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:28:38Z","timestamp":1709108918000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/2\/3\/article-p221_221.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":14,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3920\/bm2011.0013","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}