{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:29:56Z","timestamp":1791876596697,"version":"4.3.4"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>This article presents the results of original research conducted in St. Petersburg, Russia, which showed that the <jats:italic>Helicobacter pylori<\/jats:italic> strains isolated from patients with duodenal ulcer and chronic gastroduodenitis possess significantly higher levels of the pathogenicity islands (cag-PAI) genes than the strains isolated from healthy volunteers. The most frequently detected cag-PAI genes <jats:italic>were cagA<\/jats:italic> and <jats:italic>cagH<\/jats:italic> in the strains isolated from patients with chronic gastroduodenitis, and <jats:italic>cagA<\/jats:italic> and <jats:italic>cagE<\/jats:italic> in the strains isolated from patients with duodenal ulcer. A comparison of the clinical strains isolated from patients from St. Petersburg, Russia and patients from Dushanbe, Tajikistan showed that <jats:italic>cagA<\/jats:italic> gene was more prevalent in the strains from St. Petersburg. These findings demonstrate the necessity of implementation of molecular genetic identification of <jats:italic>H. pylori<\/jats:italic> in the clinical diagnostics practice reflecting the virulent genes profile of the strain. Addition of probiotics to the standard eradication therapy of <jats:italic>H. pylori<\/jats:italic> significantly improves the results of this therapy.<\/jats:p>","DOI":"10.3920\/bm2011.0023","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T18:37:13Z","timestamp":1339180633000},"page":"157-161","source":"Crossref","is-referenced-by-count":7,"title":["Helicobacter pylori-associated gastroenterological diseases: genetic features and probiotic treatment"],"prefix":"10.1163","volume":"3","author":[{"given":"N.V.","family":"Baryshnikova","sequence":"first","affiliation":[{"name":"North-West State Medical University n.a. I.I. 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