{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:48:46Z","timestamp":1780354126750,"version":"3.54.1"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:p>\n               <jats:italic>Enterococcus faecium<\/jats:italic> NCIMB 10415 reduces diarrhoea incidence and duration in animals and human study subjects.\nWe tested whether the strain is also capable of reducing chronic gut inflammation and aimed to identify mechanisms\nthat are involved in possible probiotic effects. To identify health-promoting mechanisms of the strain, we used\ninterleukin-10-deficient mice that spontaneously develop gut inflammation and fed these mice a diet containing\nNCIMB 10415 for 3, 8 and 24 weeks, respectively. Control mice were fed a diet which was identically composed\nbut did not contain the strain. After 3 weeks of intervention the experimental animals were less inflamed in the\ncaecum than the control animals. This effect was not observed in the colon and there were no differences between\nexperimental and control mice at any other time point. The application of the strain was associated with higher\nexpression levels of interferon gamma and interferon gamma-induced protein 10 after 3 and 24 but not after 8 weeks\nof feeding. No differences between the animals were observed in intestinal barrier function or intestinal microbiota\ncomposition. However, we observed a low abundance of the mucin-degrading bacterium <jats:italic>Akkermansia muciniphila<\/jats:italic>\nin the mice that were fed NCIMB 10415 for 8 weeks. These low cell numbers were associated with a significantly\nlower caecal inflammation score and improved paracellular permeability as compared to the NCIMB-treated mice\nthat were killed after 3 and 24 weeks of intervention. In conclusion, NCIMB 10415 is not capable of reducing gut\ninflammation in the IL-10<jats:sup>-\/-<\/jats:sup> mouse model. The exact role of <jats:italic>A. muciniphila<\/jats:italic> and of a possible interaction between\nthis bacterium, NCIMB 10415 and the host in gut inflammation requires further investigation.<\/jats:p>","DOI":"10.3920\/bm2011.0050","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T02:12:39Z","timestamp":1329790359000},"page":"43-50","source":"Crossref","is-referenced-by-count":21,"title":["Enterococcus faecium NCIMB 10415 does not protect interleukin-10 knock-out mice from chronic gut inflammation"],"prefix":"10.1163","volume":"3","author":[{"given":"B.","family":"Ganesh","sequence":"first","affiliation":[{"name":"German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blaut","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Loh","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2005.04.004"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.3.G764"},{"key":"atypb3","first-page":"887","volume":"31","journal-title":"A placebo-controlled trial. 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